fa تشخیص پروفایل‌های متابولومیکی و زودهنگام بیماری‌ها مبتنی بر متابولومیکس: یک مطالعه مروری روایی فيزيولوژي Physiology مقاله مروري Review Article <span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><a name="_Hlk113374001"><b><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">زمینه و هدف: </span></span></span></b></a><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">متابولومیکس </span></span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">علمی برای شناسایی مولکول</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">های کوچک موجود در بافت</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">ها و مایعات بیولوژیکی است. این متابولیت</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">ها محصول نهایی واکنش</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">های شیمیایی در سیستم بیولوژیکی هستند. متابولومیکس همراه با ابزارهای شیمی مثل</span></span></span> <span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">طیف سنجی تشدید مغناطیس هسته&shy; ای (</span></span></span><a name="_Hlk135441273"><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">Nuclear magnetic resonance</span></span></a><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">) کروماتوگرافی گازی-طیف سنجی جرمی (</span></span></span><a name="_Hlk135441094"><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">Gas chromatography&ndash;</span></span></a><a name="_Hlk135441319"><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">mass spectrometry</span></span></a><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">) می</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">تواند نقش به سزایی درتشخیص پروفایل</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">های متابولومیکی داشته باشد. پروفایل</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">‌</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">های متابولومیکی شامل مولکول</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">های کوچکی هستند که در بیماری</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">های مختلف ممکن است مقدار آنها تغییر پیدا کند. شناسایی تغییرات کمیتی این مولکول</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">های کوچک به کمک مطالعه متابولومیکس می</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">تواند در تشخیص زود هنگام بیماری</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">ها و درمان افراد کمک شایانی کند. بنابرین درک بهتر تغییرات مولکولی مرتبط با بیماری برای شناسایی مسیرهای جدید جهت درمان و تشخیص با استفاده از روش</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">های نوین ضروری است. هدف از این مطالعه مروری، معرفی علم متابولومیکس به عنوان تکنیک نوین و کاربرد آن در زمینه تشخیص و درمان زود هنگام بیماری</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">&shy;</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">ها است.</span></span></span> <span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">واژه‌های کلیدی:</span></span></span></b><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> متابولومیکس، </span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:120%">NMR, GC-MS</span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">، متابولیت </span></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><a name="_Hlk114425361"><b><span style="font-size:9.5pt"><span style="line-height:150%">Background and Objectives:</span></span></b></a><span style="font-size:9.5pt"><span style="line-height:150%"> Metabolomics is a science for identifying small molecules in biological tissues and fluids. These metabolites are the final product of chemical reactions in the biological system. Metabolomics together with chemistry tools such as nuclear magnetic resonance and gas chromatography&ndash;mass spectrometry can play a key role in identifying metabolic profiles. Metabolic profiles include small molecules, and their amount may change in different diseases. Identifying changes in the quantity of these small molecules with a metabolomics approach can help in early diagnosis of diseases and treatment of people. Therefore, accurate understanding of molecular changes related to the disease is necessary to identify new pathways for treatment and diagnosis using new methods. The purpose of this review study is to introduce the science of metabolomics as a new technique and its application in the field of early diagnosis and treatment of diseases.</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.5pt"><span style="line-height:150%">Key words:</span></span></b><span style="font-size:9.5pt"><span style="line-height:150%"> Metabolomics, GC-MS, NMR, Metabolite</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span dir="RTL" lang="FA" style="font-size:9.5pt"><span style="line-height:150%"></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.5pt"><span style="line-height:150%">Funding:</span></span></b><span style="font-size:9.5pt"><span style="line-height:150%"> This study did not have any funds. </span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.5pt"><span style="line-height:150%">Conflict of interest:</span></span></b><span style="font-size:9.5pt"><span style="line-height:150%"> None declared.</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.5pt"><span style="line-height:150%">Ethical approval:</span></span></b><span style="font-size:9.5pt"><span style="line-height:150%"> None declared.</span></span><span dir="RTL" lang="FA" style="font-size:9.5pt"><span style="line-height:150%"></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="line-height:150%"></span></b></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="line-height:150%">How to cite this article:</span></b><b> </b><span style="font-size:9.0pt"><span style="line-height:150%">Haghighat Khadijeh, </span></span><span style="font-size:9.0pt"><span style="line-height:150%">Mahmoudi</span></span><span style="font-size:9.0pt"><span style="line-height:150%"> Fariba. Diagnosis of Metabolomic Profiles and Early Detection of Diseases Based on Metabolomics: A Narrative Review</span></span><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">. </span></span><i><span style="font-size:9.0pt"><span style="line-height:150%">J Rafsanjan</span></span></i><span style="font-size:9.0pt"><span style="line-height:150%"> <i>Univ Med Sci</i> 2023; 22 (3): 277-92. [Farsi]</span></span> <b><span style="font-size:8.0pt"><span style="line-height:150%"></span></span></b></span></span></span></span></span><br> &nbsp; متابولومیکس, NMR, GC-MS, متابولیت Metabolomics, GC-MS, NMR, Metabolite 277 292 http://journal.rums.ac.ir/browse.php?a_code=A-10-5347-3&slc_lang=fa&sid=1 Khadijeh Haghighat خدیجه حقیقت f.mahmoudi@uma.ac.ir 6900319475328460053946 6900319475328460053946 No University of Mohaghegh Ardabili دانشگاه محقق اردبیلی ّFariba Mahmoudi فریبا محمودی kh.haghighat@uma.ac.ir 6900319475328460053947 6900319475328460053947 Yes University of Mohaghegh Ardabili دانشگاه محقق اردبیلی