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The Relationship between Morphological Differentiation of Colorectal Cancer with Lymph/Vascular Involvement: A Short Report
K. Ziari[1], K. Gohari Moghaddam[2], K. Alizadeh[3], M. Dadpay2
Received: 14/11/2012 Sent for Revision: 15/01/2013 Received Revised Manuscript: 06/02/2013 Accepted: 26/02/2013
Background and Objective: Lymphovascular involvement is the main and most important prognostic factor in colorectal cancer. This study aimed to evaluate the relationship of morphological differentiation and lymph/vascular involvement.
Materials and Methods: In this cross-sectional study, the pathological results of 52 colectomy patients between 2006 and 2011 in Emam-Reza and Be’sat Hospital in Tehran with pathological confirmed colorectal cancers were analyzed. The X2 test was used to compare discrete variables. The findings are presented as a frequency, percentage, mean and standard deviation.
Results: There was no association between morphological differentiation and lymph node involvement
(p= 0.936) as well as involvement of peripheral lymph nodes (p= 0.365). While the degree of morphological differentiation was significantly associated with vascular involvement (p= 0.031) and distant metastases
(p= 0.031).
Conclusion: Morphological differentiation of the tumor can predict vascular involvement and distant metastasis in colorectal carcinoma patients, although the association was not observed with the lymph nodes involvement.
Key words: Colorectal carcinoma, Morphological differentiation, Vascular involvement, Lymph nodes
Funding: This research was funded by AJA University of Medical Sciences.
Conflict of interest: None declared.
Etical approval: The Ethics Committee of AJA University of Medical Sciences approved the study.
How to cite this article: Ziari K, Gohari Moghaddam K, Alizadeh K, Dadpay M. The Relationship between Morphological Differentiation of Colorectal Cancer with Lymph/Vascular Involvement: A Short Report. J Rafsanjan Univ Med Sci 2014; 12(11): 943-8. [Farsi]
[1]- Assistabnt Prof., Dept. of Pathology, Be’sat Hospital, AJA University of Medical Sciences, Tehran, Iran
(Corresponding Author) Tel: (0311) 6683107, Fax: (0311) 6683107, E- mail: medicalresco2@yahoo.com
[2]- Assistabnt Prof., Dept. of Pathology, Imam Reza Hospital, AJA University of Medical Sciences, Tehran, Iran
[3]- GP, Researcher Be’sat Hospital, AJA University of Medical Sciences, Tehran, Iran
Received: 2012/11/13 | Accepted: 2013/09/30 | Published: 2014/03/2
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