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URL: http://journal.rums.ac.ir/article-1-2211-en.html
Background and Objective: The D-test is performed by
placing clindamycin and erythromycin
impregnated disks at a standard distance on the agar plate then looking for the
flattening of inhibition zone around the clindamycin disk. A positive D-test
indicates clindamycin
inducible resistance and also predicts treatment failure
possibility of this antibiotic in clinic. Prevalence of staphylococcal inducible resistance to
clindamycin through the D-test was the aim of
this study.
Materials
and Methods: In this descriptive-cross-sectional study, inducible resistance to
clindamycin was examined on the 150 isolated Staphylococcus aureus
(n=103) and coagulase-negative staphylococci (n=47) collected from nasal
employees and clinical samples by using D-test. The statistical analysis was performed using chi-square
test.
Results: Out of 103 isolated
S. aureus, 22 (21.4%)
were methicillin-resistant (MRSA). Among the tested samples, 3(2%), 1(0.6%) and 2(1.3%) had D, D+ and HD
phenotypes, respectively. Fifty-four (36%) of isolations exhibited resistance
to both clindamycin and erythromycin. Prevalence of resistance to clindamycin
and erythromycin between isolated MRSA and methicillin-susceptible S. aureus
(MSSA) was statistically significant (p<0.05).
Conclusion: Phenotypical
resistance to erythromycin is not always attributable to clindamycin
resistance. Therefore, staphylococcus strains resistant to erythromycin and
susceptible to clindamycin should be subjected to D-test assay.
Key words: Inducible
resistance, Clindamycin, Staphylococcus aureus, D-test
Funding: This research
was funded by Lorestan
University of Medical Sciences.
Conflict of interest: None declared.
Ethical approval: The Ethics
Committee of Lorestan University of Medical Sciences approved the study.
How to cite this article: Goudarzi Gh.R, Azadpour M. Prevalence of
Clindamycin Inducible Resistance in Staphylococcus Aureus and
Coagulase-Negative Staphylococci Using D-Test: A Short Report. J RafsanjanUniv
Med Sci 2015 14(1): 77-82. [Farsi]
Received: 2014/06/27 | Accepted: 2015/04/26 | Published: 2015/04/26
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