Volume 13, Number 10 (2-2015)                   JRUMS 2015, 13(10): 1013-1018 | Back to browse issues page


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Rasaneh S, Johari-Daha F. The Application of 99mTc-Chitosan Microparticles in Lung Imaging of Mice: A Short Report . JRUMS. 2015; 13 (10) :1013-1018
URL: http://journal.rums.ac.ir/article-1-2236-en.html

Assistant prof Nuclear Science and Technology Research Institute
Abstract:   (2636 Views)

Background and Objective: In nuclear medicine, lung perfusion scintigraphy is performed by radiolabeled particles, 99 mTc-albumin macroaggregated. Synthesizing of the particles has some difficulties. In order to resolve this problem, chitosan microparticles were used as an alternative choice. 

Materials and Methods: The qualitative control tests including: the determining particles size, the labeling efficiency and stability in saline buffer and imaging studies in the mice were performed.

Results: The size of particles was 90-110 micron. The labeling efficiency was 94±3%, the good stability in saline buffer and high accumulation of activity in mice lung were seen.

Conclusion: The results showed that the 99mTc-chitosan microparticles may be considered as a promising radiopharmaceutical of lung perfusion scintigraphy that needs more investigations.

Key words: Chitosan, Lung perfusion scintigraphy, 99mTc-albumin macroaggregated, 99mTc

 

Funding: This research was not funded by any university or organization.

Conflict of Interest: Not declared.

Ethical approval: This research was performed based on the Ethics Committee of Nuclear science and Technology institute, Helsinki ethic.

 

How to cite this article: Rasaneh S, Johari-Daha F. The Application of 99mTc-Chitosan Microparticles in Lung Imaging of Mice: A Short Report. J RafsanjanUniv Med Sci 2015 13(10): 1013-18. [Farsi]


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Type of Study: Research | Subject: Physics
Received: 2014/07/16 | Accepted: 2015/02/25 | Published: 2015/02/25

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