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The Role of Aerobic Exercise on Pain By Histamine Receptors Using Formalin Test in Mice
E. Hejazian[1], M.R. Sadeghian[2], S.H.Hejazian[3]
Received:06/07/2015 Sent for Revision: 16/09/2015 Received Revised Manuscript: 26/01/2016 Accepted: 02/02/2016
Background and Objectives: Aerobic exercise or cardio is defined as a physical exercise that causes high oxygen consumption compared to the rest and conducted to increased cardiorespiratory intensity. Different substances, can inhibit pain occurred through opioids, histaminergic, and cholinergic receptors. This study was done to determine the role of aerobic exercise in pain by histamine receptors using formalin test in mice.
Materials and Methods: In this experimental study, by use of formalin test, the analgesic effect has been used in three groups of control, test one and test two and by ranitidine which is a histamine receptores inhibitor, the analgesic effect of aerobic exercise and the role of histamine receptors were investigated. For this purpose by use of mean score of pain and two way Anova and repeated major in every 5 minute; regarding, formalin test, as a standard pain inducing, was used.
Results: Our result indicated that subcoutanous injection of formalin to the paw of the animal significantly(P<0.05) reduced the pain score in group of exercise while the mean score of pain in group that first recieved ranitidine (as histamine receptores blocker) increased and was not significantly different.
Conclusion: The analgesic effects of aerobic exercise may be induced by histamine receptors.
Key words: Aerobic exercise, Pain, Histamine receptors, Formalin, Analgesia.
Funding: This study was funded by َAzad University of Medical Sciences and Health Services
Conflict of interest: None declared.
Ethical approval: The Ethics committee of Azad University of yazd approved the study.
How to cite this article: Hejazian E, Sadeghian MR, Hejazian SH. The Role of Aerobic Exercise on Pain By Histamine Receptors Using Formalin Test in Mice. J RafsanjanUniv Med Sci 2016; 15(2): 17-26. [Farsi]
[1]- Msc Student of Sport Physiology, Azad University of Yazd, Yazd, Iran
[2]- Assistant Prof, Physical Education Department,Yazd University, Yazd, Iran
[3]- Assistant Prof, Physiology Department, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
(Corresponding Author) Tel: (0351) 8203410, Fax: (0351) 8203410, Email: hejaziansh@yahoo.com
Received: 2015/06/29 | Accepted: 2016/04/18 | Published: 2016/04/18
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