Volume 3, Issue 4 (12-2004)                   JRUMS 2004, 3(4): 243-249 | Back to browse issues page


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Taherian A, Rashidy-Pour A, Vafaei A, Jarrahi M, Miladi-Gorgi H, Emami-Abarghooii M et al . Effect of Aqueous Extract of the Coriandrum Sativum Seed on the Reduction of Acute and Chronic Pain in Mice. JRUMS. 2004; 3 (4) :243-249
URL: http://journal.rums.ac.ir/article-1-32-en.html

Abstract:   (9958 Views)

  Effect of Aqueous Extract of the Coriandrum Sativum Seed on the Reduction of Acute and Chronic Pain in M ice

 

  AA. Taherian MD ¹*, A. Rashidy-Pour PhD 2 , AA. Vafaei PhD 3 , M. Jarrahi MSc 4 , H. Miladi-Gorgi MSc 4 , M. Emami-Abarghooii PharmD 4 , H. Sadeghi BSc 5

 

  1- Academic Member, Dept. of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran

  2- Associated Professor, Dept. of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran

  3 – Assistant Professore, Dept. of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan Iran

  4- Academic Member, Dept. of Physiology, University of Medical Sciences, Semnan, Iran

  5- BSc, Dept of Physiology, Faculty of Medical Sciences, Semnan Iran

 

  Background: Previous investigations have shown that Coriandrum Sativum (CS) extract probably modulates pain in human and animal. The aim of this investigation was assessment of the role of CS on acute and chronic pain by formalin test in mice.

  Materials and Methods: In this study, 35 male albino mice in 5 groups (25-30g) were used. CS extract (100, and 200mg/kg), or saline were injected intera-peritoneal (IP) 30 mins before the formalin test. Indices of signs of pain were licking and foot elevation for assessment of acute pain (5 min), and chronic pain (15-40 min) after the injection of formalin 5% (25µl) in the right paw.

  Reasults: Results showed that although CS extract has analgesic effect in both doses in acute and chronic pain, (p<0.01) but higher doses is more effective, where as 100mg/kg reduced the acute and chronic pain 0.82 but for 200mg/kg it was 0.91.

  Conclusion: Findings of this study indicated that CS extract can modulate acute and chronic pain induced by formalin injection. Further research is required to determine the mechanisms by which CS has an inhibitory effect on pain sensation.

 

  Key words: Acute and Chronic Pain, Coriandrum Sativum, Formalin Test, Mice

 

  * Corresponding author:Tel: (0231)3328426 , Fax:0231-3331551,E-mail: Taherian99@yahoo.com

  Journal of Rafsanjan University of Medical Sciences and Health Services, 2004, 3(4): 243-249

Full-Text [PDF 1364 kb]   (1262 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2005/12/4

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