Volume 16, Issue 5 (9-2017)
JRUMS 2017, 16(5): 437-448 |
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Shahraki Mojahed L, Davari S, Hajinezhad M. The Effect of Salvia shariffi and Salvia virgata Hydroalcoholic Extracts on Some Serum Biochemical Parameters in Male Hyperlipidemic Rats. JRUMS 2017; 16 (5) :437-448
URL: http://journal.rums.ac.ir/article-1-3743-en.html
URL: http://journal.rums.ac.ir/article-1-3743-en.html
University of Zabol
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The Effect of Salvia shariffi and Salvia virgata Hydroalcoholic Extracts on Some Serum Biochemical Parameters in Male Hyperlipidemic Rats
L. Shahraki Mojahed[1], S.A. Davari[2], M.R. Hajinezhad[3]
Received: 18/04/2017 Sent for Revision: 08/05/2017 Received Revised Manuscript: 25/06/2017 Accepted: 09/07/2017
Background and Objectives: Hyperlipidemia is a progressive worldwide metabolic disorder. The aim of the present study was evaluation of effects of Salvia shariffi and Salvia virgata hydroalcoholic extracts on some serum biochemical parameters in hyperlipidemic male rats.
Materials and Methods: In this experimental study, 40 male Wistar rats were randomly divided into 4 equal groups including control, hyperlipidemic rats, and hyperlipidemic rats treated with S. virgata and S. shariffi hydroalcoholic extracts (200 mg/kg bw). High-fat diet was administered to rats for one month. Then, hyperlipidemia was confirmed by measurement of serum triglyceride and cholesterol levels and the extracts were orally treated to the groups for 21 days. Finally, serum cholesterol and triglyceride levels and hepatic enzymes were measured and the obtained data were analyzed using one-way ANOVA and Tukey's post hoc test.
Results: Comparing to the hyperlipidemic group, the serum levels of cholesterol, triglyceride, and low-density lipoprotein were significantly reduced in the treated groups but this reduction was brilliant in the group treated with S. shariffi (P<0.05). Also, both extracts were able to increase the high-density lipoprotein level but it was only significant in the group treated with S. shariffi (P<0.05). Moreover, serum levels of aspartate aminotransferase and alanine aminotransferase were significantly decreased in the treated groups comparing to the hyperlipidemic group (P<0.05 and P<0.01, respectively) but this reduction was not significant between the treated groups (P˃0.05).
Conclusion: Both extracts could improve lipid profile and liver enzymes in hyperlipidemic rats but this improvement was more pronounced in the S. shariffi treated group.
Key words: Salvia shariffi, Salvia virgata, Rat, Hyperlipidemia, Liver enzymes
Funding: This research was funded by University of Zabol.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of University of Zabol approved the study (UOZ.ECRA.2017.2316905).
How to cite this article: Shahraki Mojahed L, Davari SA, Hajinezhad MR. The Effect of Salvia shariffi and Salvia virgata Hydroalcoholic Extracts on some Serum Biochemical Parameters in Male Hyperlipidemic Rats. J Rafsanjan Univ Med Sci 2017; 16(5): 437-48. [Farsi]
[1]-Graduated from Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
L. Shahraki Mojahed[1], S.A. Davari[2], M.R. Hajinezhad[3]
Received: 18/04/2017 Sent for Revision: 08/05/2017 Received Revised Manuscript: 25/06/2017 Accepted: 09/07/2017
Background and Objectives: Hyperlipidemia is a progressive worldwide metabolic disorder. The aim of the present study was evaluation of effects of Salvia shariffi and Salvia virgata hydroalcoholic extracts on some serum biochemical parameters in hyperlipidemic male rats.
Materials and Methods: In this experimental study, 40 male Wistar rats were randomly divided into 4 equal groups including control, hyperlipidemic rats, and hyperlipidemic rats treated with S. virgata and S. shariffi hydroalcoholic extracts (200 mg/kg bw). High-fat diet was administered to rats for one month. Then, hyperlipidemia was confirmed by measurement of serum triglyceride and cholesterol levels and the extracts were orally treated to the groups for 21 days. Finally, serum cholesterol and triglyceride levels and hepatic enzymes were measured and the obtained data were analyzed using one-way ANOVA and Tukey's post hoc test.
Results: Comparing to the hyperlipidemic group, the serum levels of cholesterol, triglyceride, and low-density lipoprotein were significantly reduced in the treated groups but this reduction was brilliant in the group treated with S. shariffi (P<0.05). Also, both extracts were able to increase the high-density lipoprotein level but it was only significant in the group treated with S. shariffi (P<0.05). Moreover, serum levels of aspartate aminotransferase and alanine aminotransferase were significantly decreased in the treated groups comparing to the hyperlipidemic group (P<0.05 and P<0.01, respectively) but this reduction was not significant between the treated groups (P˃0.05).
Conclusion: Both extracts could improve lipid profile and liver enzymes in hyperlipidemic rats but this improvement was more pronounced in the S. shariffi treated group.
Key words: Salvia shariffi, Salvia virgata, Rat, Hyperlipidemia, Liver enzymes
Funding: This research was funded by University of Zabol.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of University of Zabol approved the study (UOZ.ECRA.2017.2316905).
How to cite this article: Shahraki Mojahed L, Davari SA, Hajinezhad MR. The Effect of Salvia shariffi and Salvia virgata Hydroalcoholic Extracts on some Serum Biochemical Parameters in Male Hyperlipidemic Rats. J Rafsanjan Univ Med Sci 2017; 16(5): 437-48. [Farsi]
[2]- Assistant Prof., Dept. of Pathobiology, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
(CorrespondingAuthor), Tel: (054) 34822253, Fax: (054) 32240735, Email:davari.aida1@gmail.com
(CorrespondingAuthor), Tel: (054) 34822253, Fax: (054) 32240735, Email:davari.aida1@gmail.com
[3]- Assistant Prof., Dept. of Basic Science, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
Type of Study: Research |
Subject:
علوم آزمايشگاهي
Received: 2017/03/18 | Accepted: 2017/07/9 | Published: 2017/09/17
Received: 2017/03/18 | Accepted: 2017/07/9 | Published: 2017/09/17
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