Volume 16, Issue 6 (10-2017)
JRUMS 2017, 16(6): 541-552 |
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Ghobadi M, Arji roodsari B, Yadegari M, Homayouni-Moghadam F, Rezvani M. The Effect of Ferulic Acid on Cognitive Disorder And Brain Structural Deficit in Mice in Cuprizone Induced Animal Model of Multiple Sclerosis. JRUMS 2017; 16 (6) :541-552
URL: http://journal.rums.ac.ir/article-1-3751-en.html
URL: http://journal.rums.ac.ir/article-1-3751-en.html
Yazd-Shahid Sadoughi University of medical sciences, dept Physilogy
Abstract: (4908 Views)
Background and Objective: Ferulic acid is a polyphenolic compound derived from some fruit and different cereals. Previous studies have shown that this compound has antioxidant, anti-apoptosis, and differentiation properties in the nervous system. The aim of this study was to evaluate the effect of ferulic acid on the death of oligodendrocytes and demyelination in male C57B6 / J mice in cuprizone induced animal model of multiple sclerosis.
Material and methods: In this study, demyelination was induced by oral administration of rats with the 0.2% cuprizone that was added to the usual diet during 6 weeks. Animals were fed daily with ferulic acid at doses of 10or 100 mg / kg of body weight. At the end of the sixth week, the passive avoidance and Y maze test were performed. Then, animal brains were removed and fixed to histological studies using Luxol–Fast-Blue staining
Results: The results of this study showed that ferulic acid reduced the random entry of animals into the arms of the Y maze in compared to the cuprizone treated group [p<0.01], but the sequential entry of animals into the Y maze were significantly increased [P<0.05]. A significant improvement in passive avoidance test was observed in the groups treated with ferulic acid at dose of 10 [p<0.05]. Histological evaluations showed the lower demyelination in Luxol-Fast-Blue in the group treated with ferulic acid.
Conclusion: The results of this study showed that ferulic acid plays a neuroprotective role in cuprizone models of multiple sclerosis through reducing neuronal demyelination and oligodendrocytes death.
Key words: Ferulic acid, Demyelination, Memory, Cuprizone, Mice
Funding: This research was funded by Shahid Sadoughi University of Medical Sciences
Conflict of interest: None declared.
Ethical approval: The Ethical Committee of Shahid Sadoughi University of Medical Sciences approved the study.
How to cite this article: Ghobadi M, Arji roodsari B, Yadegari M, Homayouni-Moghadam F, Rezvani M.E. The Effect of Ferulic Acid on Cognitive Disorder And Brain Structural Deficit in Mice in Cuprizone Induced Animal Model of Multiple Sclerosis. J Rafsanjan Univ Med Sci 2017; 16(6): 541-52. [Farsi]
Material and methods: In this study, demyelination was induced by oral administration of rats with the 0.2% cuprizone that was added to the usual diet during 6 weeks. Animals were fed daily with ferulic acid at doses of 10or 100 mg / kg of body weight. At the end of the sixth week, the passive avoidance and Y maze test were performed. Then, animal brains were removed and fixed to histological studies using Luxol–Fast-Blue staining
Results: The results of this study showed that ferulic acid reduced the random entry of animals into the arms of the Y maze in compared to the cuprizone treated group [p<0.01], but the sequential entry of animals into the Y maze were significantly increased [P<0.05]. A significant improvement in passive avoidance test was observed in the groups treated with ferulic acid at dose of 10 [p<0.05]. Histological evaluations showed the lower demyelination in Luxol-Fast-Blue in the group treated with ferulic acid.
Conclusion: The results of this study showed that ferulic acid plays a neuroprotective role in cuprizone models of multiple sclerosis through reducing neuronal demyelination and oligodendrocytes death.
Key words: Ferulic acid, Demyelination, Memory, Cuprizone, Mice
Funding: This research was funded by Shahid Sadoughi University of Medical Sciences
Conflict of interest: None declared.
Ethical approval: The Ethical Committee of Shahid Sadoughi University of Medical Sciences approved the study.
How to cite this article: Ghobadi M, Arji roodsari B, Yadegari M, Homayouni-Moghadam F, Rezvani M.E. The Effect of Ferulic Acid on Cognitive Disorder And Brain Structural Deficit in Mice in Cuprizone Induced Animal Model of Multiple Sclerosis. J Rafsanjan Univ Med Sci 2017; 16(6): 541-52. [Farsi]
Type of Study: Research |
Subject:
Physiology
Received: 2017/04/6 | Accepted: 2017/10/14 | Published: 2017/10/14
Received: 2017/04/6 | Accepted: 2017/10/14 | Published: 2017/10/14
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