Volume 17, Issue 3 (5-2018)                   JRUMS 2018, 17(3): 201-212 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Tohidi N, Ghorbian S. Investigating the Association of RAN (rs 14035) and XPO5 (rs 2257082) Genes Polymorphisms with the Recurrent Pregnancy Loss in Women Referred to Imam Khomeini Hospital of Ardabil During 2015-2017 Years. JRUMS. 2018; 17 (3) :201-212
URL: http://journal.rums.ac.ir/article-1-3978-en.html
1. M.SC in Cellular and Molecular Biology-Genetic Ahar Branch, Islamic Azad University, Ahar, Iran.
Abstract:   (174 Views)
Background and Objectives: XPO5 is one of the important molecules that has been identified in the trophoblast cells of the placenta, which is involved in the miRNAs biogenesis and processing. RAN is the other protein, which is involved in the miRNAs processing. The presence of RAN (rs 14035) and XPO5 (rs 2257082) genes may affect the genes expression adjustment in the mother’s uterine and lead to the recurrent abortion. The aim of this investigation was to evaluate the association of rs 14035 and rs 2257082 genes polymorphism with the recurrent pregnancy loss (RPL) in women referred to Imam Khomeini Hospital of Ardabil during 2015-2017 Years.
Materials and Methods: This descriptive study included 100 women with RPL with unknown reason and 100 women that had a successful pregnancy without abortion, and with an alive child, which referred to Imam Khomeini Hospital of Ardabil during 2015-2017 years. After DNA extraction, by PCR-RFLP method, the frequencies of these polymorphisms were evaluated and data were analyzed using chi-square test.
Results: There was a significant association between the CC/CT+TT and CT/CC+TT genotypes in XPO5 gene polymorphism and the risk of abortion (p=0.041). Whereas, the genotypes frequency of RAN gene polymorphism did not reveal any statistical significant difference across the two groups (p=0.516).
Conclusion: The findings revealed that XPO5 gene polymorphism may be contributed as a predisposing risk factor to RPL in the pregnant women. Whereas, it seems that the RAN gene polymorphism cannot be considered as a risk factor for predisposing of RPL.
Key words: Gene, Polymorphism, XPO5, RAN, Recurrent pregnancy loss, Ardabil
 
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Islamic Azad University of Ahar Branch approved the study.
 
How to cite this article: Tohidi N, Ghorbian S. Investigating the Association of RAN (rs 14035) and XPO5 (rs 2257082) Genes Polymorphisms with the Recurrent Pregnancy Loss in Women Referred to Imam Khomeini Hospital of Ardabil During 2015-2017 Years. Univ Med Sci 2018; 17 (3): 201-12. [Farsi]
 
Full-Text [PDF 222 kb]   (65 Downloads) |   |   Full-Text (HTML)  (43 Views)  
Type of Study: Research | Subject: زيست شناسي
Received: 2017/09/27 | Accepted: 2018/04/16 | Published: 2018/05/30

Add your comments about this article : Your username or Email:
Write the security code in the box

Send email to the article author


© 2018 All Rights Reserved | Journal of Rafsanjan University of Medical Sciences

Designed & Developed by : Yektaweb