Volume 17, Issue 11 (1-2019)                   JRUMS 2019, 17(11): 1017-1030 | Back to browse issues page

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Honari N, Pouraboli I. The Effect of Hydroalcoholic Extract of Thymus caramanicus on Serum Testosterone and Testis Antioxidant Enzymes Levels in Streptozotocin Induced Diabetic Rats: An Experimental Study. JRUMS 2019; 17 (11) :1017-1030
URL: http://journal.rums.ac.ir/article-1-4089-en.html
Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman
Abstract:   (3698 Views)
Background and Objectives: Diabetes mellitus is accompanied by oxidative stress and leads to reproductive disorders. With respect to antioxidants present in Thymus caramanicus, the effect of hydroalcoholic extract of it on testis weight, serum testosterone, lipid peroxidation and testis antioxidant enzymes levels were investigated in streptozotocin (STZ) induced diabetic male rats
Materials and Methods: In this experimental study, in order to induce  experimental diabetes model, a single dose (65 mg/kg, i.p) of STZ was intraperitoneally injected in rats. After 7 days, diabetic rats with fasting blood glucose level above 250 mg/dl were divided into 3 groups of 6 and received distilled water (1 mL), extract (500 mg/kg), glibenclamide (20 mg/kg) individually by gavage for 14 days. One group of normal animals were also used. At the end of treatments period, fasting rats were anaesthetized, and blood samples were collected for serum testosterone level measurement. Rats’ testes were also used for evalauation of catalase (CAT) and superoxide dismutase (SOD) antioxidant enzymes activities and malondialdehyde (MDA) level. Statistical analysis of data was performed using one-way ANOVA and Tukey’s post-hoc test.
Results: Administration of T. caramanicus extract in diabetic rats, significantly increased testis and body weight, serum levels of testosterone, catalase (p<0.001) and superoxide dismutase enzymes activities (p<0.047) in testis but significantly decreased MDA level (p<0.004).
Conclusion: Hydroalcoholic extract of T. caramanicus had beneficial effects on male reproductive system and exerted antilipid peroxidative and antioxidant properties in the testis of diabetic rats.
Key words: Thymus caramanicus, Diabetes mellitus, Antioxidant, Rat, Testis
 
Funding: This study was funded by Ministry of Science, Research and Technology and Shahid Bahonar University of Kerman.
Conflict of interest: None declared.
Ethical approval: This study was approved by the Ethics Committee of Shahid Bahonar University of Kerman. (Ethical number: 1394)
 
How to cite this article: Honari N, Pouraboli I. The Effect of Hydroalcoholic Extract of Thymus caramanicus on Serum Testosterone and Testis Antioxidant Enzymes Levels in Streptozotocin Induced Diabetic Rats: An Experimental Study. J Rafsanjan Univ Med Sci 2019; 17 (11): 1017-30. [Farsi]
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Type of Study: Research | Subject: Physiology
Received: 2017/12/19 | Accepted: 2018/12/5 | Published: 2019/01/15

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