Volume 7, Issue 2 (9-2008)                   JRUMS 2008, 7(2): 131-136 | Back to browse issues page

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Abstract:   (10447 Views)
Background and Objectives: Some nursing and medicine activities may increase the production of free radicals in patients. Therefore, this study was performed to determine the effect of suction with a tube located inside of the trachea on the amount of oxidative stress indexes in CABG patients. Matrial and Methods: This clinical study was performed on 35 patients which were under coroner vascular graft surgery. Blood samples were collected 3 times (before, immediatery and 15 minutes after suction) and then, the amounts of glutathione and the activity of glutathione peroxidase were measured. Results: Results of this study showed that both glutathione and glutathione peroxidase activity are significantly decreased both in immediately and 15 minutes after suction comparing to before suction (p<0.001). Conclusions: Suction is a free radical producing process which causes some changes in activities of anti-oxidants. The defect of anti- oxidants related defense of body causes oxidative stress. Therefore, further studies are needed to find out a way to overcom this problem. Key words: Endotracheal Suction, Glutathione (GSH), Glutathione Peroxidas (GSH-P) Funding: This research was funded by Baghiatallah Medical Sciences University. Conflict of interest: None declared. Ethical approval: The Ethics Committee of Baghiatallah Medical Sciences University approved the study.
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Type of Study: Research | Subject: Nursing
Received: 2008/12/28