Volume 3, Number 2 (6-2004)                   JRUMS 2004, 3(2): 67-75 | Back to browse issues page


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Salmanroghani H, Kargar S, Butorabi Z. Comparison of the Effects of Two Different Doses of Botulinum Toxin in the Treatment of Chronic Anal Fissure. JRUMS. 2004; 3 (2) :67-75
URL: http://journal.rums.ac.ir/article-1-49-en.html

استاديار بخش داخلي و فوق تخصص بيماري‌هاي گوارش و كبد
Abstract:   (12396 Views)
Comparison of the Effects of Two Different Doses of Botulinum Toxin in the Treatment of Chronic Anal Fissure

 

  H. Salmanroghani MD1*, S. Kargar MD2, Z. Butorabi MD3

 

  1- Assistant Professor, Dept. of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

  2- Assistant Professor, Dept. of Surgery,. Shahid Sadoughi University of Medical Sciences, Yazd, Iran

  3- Assistant Professor, Dept. of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

 

 

  Background: Chronic anal fissure is a common disease of the anorectal area. According to manometric studies, the increase of anal sphincter pressure is the most common cause of chronic anal fissure. Therefore, treatment is focused on decreasing the anal sphincter pressure. The injection of botulinum toxin into anal sphincter is one of the treatments, but its ideal dose has not been identified yet.

  The aim of the study was to compare the effects of the two different doses of toxin on fissure healing rate, and also assessement of the complication of the treatment.

  Materials and Methods: 70 patients with history of more than 3 months anal problem, with signs of chronic anal problems, such as skin tag and or visible internal anal sphincter muscle fiber at the base of ulcer were enrolled.

  Results: 38 patients were men and 32 patients were women. Mean age was 35.3+11.2 years, and average length of illness was 10.29+4.15 months. The results showed 82.85% of patients had posterior anal fissure. The most common symptom was pain with defecation. In each group, four patients were lost from the study and 62 patients completed the study. One of the patients from the low dose group (I) and 4 patients from the high dose group (II) had gas incontinence. After one week, only 4 patients from the high dose group (II) had recovery, but no patient of the low dose group (I) had recovery. After two weeks, 20% of the patients in group I and 50% of the patients in group (II) had recovery. After 8 weeks, 80% of the patients in the group I and 90.6% of group II had recovery (P=0.29). Two patients in group I had rapid recurrence before six months. There wasn't any rapid recurrence in group II .At the end of the study, 22 patients from group I and 29 patients from group II had complete recovery. Six patients from group I and 3 from group II showed no response to the treatment, and most of them had chronic anterior part fissure. Four patients in group I and 2 patients in group II had recurrence after the one year follow-up.

  Conclusion: It seems that higherdoses of botulinum toxin in-patients with chronic anal fissure increases the treatment response without permanent side effects.

 

  Key words: Chronic anal fissure, Botulism toxin, Anorectal

 

  * Corresponding author Tel: (0351) 8224000

  Journal of Rafsanjan University of Medical Sciences and Health Services, 2004, 3(2): 67-75

Full-Text [PDF 235 kb]   (1553 Downloads)    
Type of Study: Research | Subject: Internal Medicine
Received: 2005/12/7

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