Volume 19, Issue 5 (8-2020)                   JRUMS 2020, 19(5): 485-498 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Panahzadeh F, Mirnasuri R, Rahmati M. The Effect of Endurance Training on the Expression of PRDX6 and KAT2B Genes in Hippocampus of Beta Amyloid-Induced Rat Model of Alzheimer's Disease: An Experimental Study. JRUMS 2020; 19 (5) :485-498
URL: http://journal.rums.ac.ir/article-1-5389-en.html
Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, IR Iran
Abstract:   (1913 Views)
Background and Objectives: Alzheimer's disease is the most common form of dementia. KAT2B (Lysine Acetyltransferase 2B) is a mitochondrial protein known as mitochondria clearing control organ by mitophagy. PRDX6 (Peroxiredoxin 6) is a key regulator of mitophagy and plays a critical role in maintaining mitochondrial ROS (Reactive oxygen species) homeostasis. Therefore, the purpose of this study was to investigate the effect of swimming endurance training on expression of PRDX6 and KAT2B genes in male hippocampus model of Wistar rat after induction of Alzheimer's.
Materials and Methods: In this experimental study, 18 rats were randomly divided into 3 groups including control, Alzheimer's and exercise-Alzheimer's groups. The Alzheimer's model was created by injecting beta 42-1 amyloid into the CA1 hippocampus region, and the training group rats participated in the swimming 30 min/day for a period of 3 weeks. In order to confirm the Alzheimer's model, thioflavin staining was used, and Real Time PCR method was used to determine the expression of the desired genes. One-way ANOVA with Tukey’s post-hoc test was used for data analysis.
Results: There was a significant difference between the amount of beta-amyloid plaques in the two groups of Alzheimer's and control (p<0.001). Alzheimer's disease significantly reduced the expression of PRDX6 and KAT2B genes in the Alzheimer's rats hippocampus (p<0.001), and also following the endurance exercise, the PRDX6 gene expression increased compared with the Alzheimer's group (p=0.027).
Conclusion: Endurance training can possibly maintain oxidative balance and improve mitochondrial hemostasis in Alzheimer's disease.
Key words: Alzheimer, Endurance training, Rat, PRDX6, KAT2B
 
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of the Faculty of Veterinary Medicine, Lorestan University, approved the study (LU.ECRA.2018.17).
 
How to cite this article: Panahzadeh F, Mirnasuri R, Rahmati M. The Effect of Endurance Training on the Expression of PRDX6 and KAT2B Genes in Hippocampus of Beta Amyloid-Induced Rat Model of Alzheimer's Disease: An Experimental Study. J Rafsanjan Univ Med Sci 2020; 19 (5): 485-98. [Farsi]
Full-Text [PDF 375 kb]   (867 Downloads) |   |   Full-Text (HTML)  (1502 Views)  
Type of Study: Research | Subject: تربيت بدني
Received: 2020/06/2 | Accepted: 2020/07/13 | Published: 2020/08/30

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Rafsanjan University of Medical Sciences

Designed & Developed by : Yektaweb