Volume 2, Number 3 and 3-4 (9-2003)                   JRUMS 2003, 2(3 and 3-4): 187-194 | Back to browse issues page


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Heidari M, Bayat M. Effects of methanolic extract of Papaver somniferum L.On seizure induced by picrotoxin in mice. JRUMS. 2003; 2 (3 and 3-4) :187-194
URL: http://journal.rums.ac.ir/article-1-65-en.html

گروه‌ سم‌شناسي‌ و فارماكولوژي‌
Abstract:   (9976 Views)

  Effects of methanolic extract of Papaver somniferum L.

  On seizure induced by picrotoxin in mice.

 

 Authors: Heidari M.R., Bayat M.

  Dept of pharmacology and toxicology faculty of pharmacy, Kerman.

 

  There are some reports about useful effect of some medicinal herbs in treatment of diseases, in traditional medicine.

  One of this reports, is the useful effect of Papaver somniferum L. on seizure.

  In this investigation, the effects of methanolic extract of Papaver somniferum L. seeds in seizure induced by picrotoxin was studied in mice.

  In this study the animals pretreated with different doses of methanolic extract (12.5, 25, 50, 100 and 200 mg/kg) by intraperitoneal injection. 20 minutes after extract injection, each animal received 12mg/kg picrotoxin for induction of seizure. Latency time for beginning of seizure, duration of seizure and death time were determined in experimental and control groups.

  The results showed that latency of begining time of seizure was increased in groups that pretreated with different doses of extract, specially with dose of 200mg/kg, (P<0.01). The duration of seizure increased in all groups of animals, but the severity of seizures was milder than control group. Different doses of extract, specially dose of 50mg/kg delayed the death time in mice (P<0.05).

  The extract of Papaver somniferum L. delayed the onset of seizure, decresed the severity of seizure induced by picrotoxin and lenghtened the death time, therefore it is a suitable agent for continuing investigation as anticonvulsant drug.

 

 Key words: Papaver somniferum L.- Seizure - Picrotoxin - Mice.

Full-Text [PDF 281 kb]   (2357 Downloads)    
Type of Study: Research | Subject: Pharmacology
Received: 2005/12/10

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