Volume 8, Number 4 (12-2009)                   JRUMS 2009, 8(4): 263-272 | Back to browse issues page


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Eizadi M, Eghdami A, Khorshidi D, Doali H, Kiani F. The Effect of L-Carnitine and Heparin Supplementation on Plasma Glucose and Lactate Concentration During Exercise. JRUMS. 2009; 8 (4) :263-272
URL: http://journal.rums.ac.ir/article-1-656-en.html

Abstract:   (9105 Views)

  The Effect of L-Carnitine and Heparin Supplementation on Plasma Glucose and Lactate Concentration During Exercise

 

  M. Eizadi [1] , A. Eghdami [2] , D. Khorshidi [3] , H. Doali3, F. Kiani3

 

  Received: 17/02/09 Sent for Revision: 14/06/09 Received Revised Manuscript: 01/11/09 Accepted: 07/11/09

 

  Background and Objectives: It has been reported that the increase of Free Fatty Acid (FFA) availability increases fat oxidation and decreases carbohydrate use in the skeletal muscles . This study was performed to determine the effect of L-carnitine supplementation plus heparin infusion on carbohydrate metabolism during aerobic exercise.

  Materials and Methods: In this clinical trail study, 30 healthy untrained male students from Islamic Azad University of Saveh, in two groups of experimental and control, cycled according to Astrand protocol on two separate occasions in a week in two steps: 1) Exercise protocol without heparin infusion or L-carnitine ingestion for the experimental group and without lactose (placebo) for the control group. Step 2) Exercise protocol after heparin infusion and L-carnitine ingestion among the experimental group and infusion and ingestion of lactose (placebo) among the control group. Blood samples were drawn immediately following the two step exercises for the purpose of plasma glucose and L-carnitine concentration calculations. The data was analysed using T-test.

  Results: The findings showed that heparin infusion and L-carnitine ingestion had no influence on plasma glucose concentrations (91±6 versus 91±7 mg/dL) in the experimental group. In addition, Lactate concentration did not change significantly in the experimental group (5.1±0.61 versus 4.47±0.59 mg/dL). Also the lactose use did not change the dependant variables in the control group.

  Conclusion: Results indicated that increased FFA availability does not affect carbohydrate metabolism or endurance performance. Further studies are necessary to determine the effect of these supplementations on fat-carbohydrate metabolism or endurance exercise.

  Key words: L-carnitine, Heparin, Glucose Metabolism, Exercise, Free Fatty Acid

 

  Funding: This research was funded by Islamic Azad University, Saveh Branch.

  Conflict of interest: None declared.

  Ethical approval: The Ethical Committee of Islamic Azad University, Saveh Branch approved the study.



 

  [1] - Academic Member, Dept. of Physical Education and Sport Sciences, Islamic Azad University, Saveh Branch , Iran

  (Corresponding Author) Tel: (0255) 2221954, Fax: (0255)2221954, E-mail: izadimojtaba 2006@yahoo.com

  [2] - Academic Member, Dept. of Biochemistry, Islamic Azad University, Saveh Branch , Iran

  [3] - Academic Member, Dept. of Physical Education and Sport Sciences, Islamic Azad University, Saveh Branch , Iran

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Type of Study: Applicable | Subject: تربيت بدني
Received: 2010/01/6

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