Volume 8, Number 4 (12-2009)                   JRUMS 2009, 8(4): 295-302 | Back to browse issues page


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Kazemi Arababadi M, Hassanshahi G, Rezaeian M, Rezazadeh Zarandi E, Vazirinejad R. Evaluation of Occult Hepatits B Virus Infection in Thalassemic Patients Infected by HCV in Kerman Province of Iran. JRUMS. 2009; 8 (4) :295-302
URL: http://journal.rums.ac.ir/article-1-659-en.html

Abstract:   (8750 Views)

  Evaluation of Occult Hepatits B Virus Infection in Thalassemic Patients Infected by HCV in Kerman Province of Iran

 

  M. Kazemi Arababadi [1] , Gh. Hassanshahi [2] , M. Rezaeian [3] , E. Rezazadeh Zarandi [4] , R. Vazirinejad [5]

 

  Received: 03/01/09 Sent for Revision: 08/03/09 Received Revised Manuscript: 31/10/09 Accepted: 20/12/09

 

  Background and Objectives: Thalassemic patients are at risk of blood transmitted infectious diseases such as hepatitis B and C, due to continued receiving of blood and its components . The aim of this study was to investigate the prevalence of occult Hepatits B Virus infection (OBI) and HBV markers in thalassemic patients with Hepatitis C infection.

  Materials and Methods : In this cross-sectional study, 60 thalassemic patients were examined for HCV infection by Reverse Transcription-PCR (RT-PCR) during Apr-Sep 2007 in the Kerman province of Iran. Hepatitis B virus infection was evaluated in the HCV positive thalassemic patients by PCR. Anti-HBc, anti-HBs and HBsAg were detected using ELISA.

  Results : Results indicated that although 27 (45%) of the cases, out of 60, were infected by HCV, but HBV-DNA was not detected in the HCV infected patients. The findings also showed that 9 (33%) out of 27 HCV-RNA positive patients were anti-HBc positive and 11 (40.7%) out of 27 patients were positive for anti-HBs.

  Conclusion: Results of this study indicated that the prevalence of OBI was very low in thalassemic patients (in contrast to HCV infection). However, this value is probably due to the inhibitory effects of HCV on host cell translation system which affects HBV protein translation.

  Key words: H epatitis B , H epatitis C, Hepatitis C Virus , Hepatitis B Virus , O ccult Hepatitis B Infection, Thalassemia

 

  Funding: This research was funded by Rafsanjan University of Medical Sciences.

  Conflict of interest: None declared.

  Ethical approval: The Ethical Committee of Rafsanjan University of Medical Sciences approved the study.



 

  [1] - Instructor , Dept. of Microbiology and Immunology, Faculty of Medicine, University of Medical Sciences, Rafsanjan, Iran

  (Corresponding Author) Tel: (0391)5234003, Fax: (0391) 5225209, E-mail: kazemi24@yahoo.com

  [2] - Assistant Prof., Dept. of Hematology, Faculty of Medicine, University of Medical Sciences, Rafsanjan, Iran

  [3] - Associate Prof., Dept. of Social Medicine, Faculty of Medicine , University of Medical Sciences, Rafsanjan, Iran

  [4] - Instructor, Dept. of Microbiology, Faculty of Medicine, University of Medical Sciences, Rafsanjan, Iran

  [5] - Associate Prof., Dept. of Social Medicine, Faculty of Medicine, University of Medical Sciences, Rafsanjan, Iran

Full-Text [PDF 218 kb]   (1423 Downloads)    
Type of Study: Applicable | Subject: Microbiology
Received: 2010/01/6

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