Volume 21, Issue 10 (1-2023)
JRUMS 2023, 21(10): 1007-1024 |
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Ethics code: IR.ZBMU.REC.1400.028
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Amirkhizi F, Hamedi-Shahraki S, Sharifan S, Pishdadian A. The Relationship Between Serum Levels of Vitamin D and Some Metabolic Indicators in Patients with Non-Alcoholic Fatty Liver Disease Referred to Sheikh Alreis Clinic in Tabriz: A Descriptive Study. JRUMS 2023; 21 (10) :1007-1024
URL: http://journal.rums.ac.ir/article-1-6636-en.html
URL: http://journal.rums.ac.ir/article-1-6636-en.html
Zabol University of Medical Sciences
Abstract: (269 Views)
Background and Objectives: Since vitamin D has been shown to have an important function in the regulation of metabolic pathways, this study aimed to investigate the association between serum levels of vitamin D with a number of metabolic indicators in patients with non-alcoholic fatty liver disease (NAFLD).
Materials and Methods: This descriptive study was conducted on 122 patients with NAFLD referred to Sheikh Alreis Clinic in Tabriz, who were categorized into "vitamin D sufficient" (n=46) and "vitamin D deficient" (n=76) based on their serum vitamin D concentrations. NAFLD was diagnosed by upper abdomen ultrasonography, and the fasting serum concentrations of glucose (FBS), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c), high- density lipoprotein cholesterol (HDL-c) as well as Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were measured as metabolic markers. Serum concentration of liver transaminase enzymes and liver steatosis severity were assessed as liver function criteria.
Results: Serum concentrations of insulin (p=0.024), LDL-c (p<0.001), and HOMA-IR (p=0.011) were significantly higher in the NAFLD patients with vitamin D deficiency compared to the patients with sufficient vitamin D. Moreover, vitamin D deficient patients had higher NAFLD histologic severity (p=0.042) and serum concentrations of alanine aminoteransferase (ALT) compared to the NAFLD patients with vitamin D sufficiency (p=0.005). Vitamin D-deficient patients were at higher odds for having hypercholesterolemia (p=0.009) and high LDL-c (p=0.011) than ones with sufficient vitamin D status even when adjusted for confounders.
Conclusion: Vitamin D deficiency in the patients with NAFLD was found to be associated with higher odds of an unfavorable lipid profile and NAFLD histologic severity.
Key words: Serum vitamin D, Lipid profile, Serum glucose, Insulin resistance, Non-alcoholic fatty liver
Funding: This study was funded by Zabol University of Medical Sciences.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Zabol University of Medical Sciences approved the study (IR.ZBMU.REC.1400.028).
How to cite this article: Amirkhizi Farshad, Hamedi-Shahraki Soudabeh, Sharifan Shima, Pishdadian Abbas. The Relationship Between Serum Levels of Vitamin D and Some Metabolic Indicators in Patients with Non-Alcoholic Fatty Liver Disease Referred to Sheikh Alreis Clinic in Tabriz: A Descriptive Study. J Rafsanjan Univ Med Sci 2023; 21 (10): 1007-24. [Farsi]
Materials and Methods: This descriptive study was conducted on 122 patients with NAFLD referred to Sheikh Alreis Clinic in Tabriz, who were categorized into "vitamin D sufficient" (n=46) and "vitamin D deficient" (n=76) based on their serum vitamin D concentrations. NAFLD was diagnosed by upper abdomen ultrasonography, and the fasting serum concentrations of glucose (FBS), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c), high- density lipoprotein cholesterol (HDL-c) as well as Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were measured as metabolic markers. Serum concentration of liver transaminase enzymes and liver steatosis severity were assessed as liver function criteria.
Results: Serum concentrations of insulin (p=0.024), LDL-c (p<0.001), and HOMA-IR (p=0.011) were significantly higher in the NAFLD patients with vitamin D deficiency compared to the patients with sufficient vitamin D. Moreover, vitamin D deficient patients had higher NAFLD histologic severity (p=0.042) and serum concentrations of alanine aminoteransferase (ALT) compared to the NAFLD patients with vitamin D sufficiency (p=0.005). Vitamin D-deficient patients were at higher odds for having hypercholesterolemia (p=0.009) and high LDL-c (p=0.011) than ones with sufficient vitamin D status even when adjusted for confounders.
Conclusion: Vitamin D deficiency in the patients with NAFLD was found to be associated with higher odds of an unfavorable lipid profile and NAFLD histologic severity.
Key words: Serum vitamin D, Lipid profile, Serum glucose, Insulin resistance, Non-alcoholic fatty liver
Funding: This study was funded by Zabol University of Medical Sciences.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Zabol University of Medical Sciences approved the study (IR.ZBMU.REC.1400.028).
How to cite this article: Amirkhizi Farshad, Hamedi-Shahraki Soudabeh, Sharifan Shima, Pishdadian Abbas. The Relationship Between Serum Levels of Vitamin D and Some Metabolic Indicators in Patients with Non-Alcoholic Fatty Liver Disease Referred to Sheikh Alreis Clinic in Tabriz: A Descriptive Study. J Rafsanjan Univ Med Sci 2023; 21 (10): 1007-24. [Farsi]
Keywords: Serum vitamin D, Lipid profile, Serum glucose, Insulin resistance, Non-alcoholic fatty liver
Type of Study: Research |
Subject:
تغذيه
Received: 2022/07/28 | Accepted: 2022/12/28 | Published: 2023/01/20
Received: 2022/07/28 | Accepted: 2022/12/28 | Published: 2023/01/20
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