Volume 4, Number 1 (9-2005)                   JRUMS 2005, 4(1): 35-39 | Back to browse issues page


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S.Lotfi A, Mohammadian Yajloo M, Mesbah Namin S, Hasannia S, Beiglarzadeh M, Gholamhosein Goodarzi B. The Frequency of the Alpha-1-antitrypsin M1, M2, M3, S and Z Variants in Iranian Population. JRUMS. 2005; 4 (1) :35-39
URL: http://journal.rums.ac.ir/article-1-7-en.html

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Abstract:   (8177 Views)

  The Frequency of the Alpha-1-antitrypsin M1, M2, M3, S and Z Variants in Iranian Population

 

  A.S. Lotfi PhD1*, M. Mohammadian Yajloo2, S.A. Mesbah Namin PhD3, S. Hasannia MSc4, M. Beiglarzadeh5, B. Gholamhosein Goodarzi MSc6

 

  1*-Associated Professor, Dept. of Clinical Biochemistry, Tarbiat Modarres University, Tehran, Iran.

  2-Student PhD, Dept. of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

  3-Assistant Professor, Dept. of Clinical Biochemistry, Tarbiat Modarres University, Tehran, Iran.

  4-Academic Member (Instructor), Dept. of Biology, Guilan University, Rasht, Iran.

  5-Student of MD, Faculty of Medicine, Tabriz University of C, Tabriz, Iran.

  6- Academic Member, Dept. of Biochemistry Razi, Research and vaccine Production center, Tehran, Iran.

 

  Background : Alpha-1-antitrypsin (AAT) has many different genetic variants but the most prevalent alleles that cause AAT deficiency are S and Z variants. The allele frequencies of AAT variants, have been identified in many countries but there were not any statistical reports on Iranian population. Therefore, the aim of this study was to investigate the frequency of M1, M2, M3, S and Z variants in Iran.

  Materials and Methods : In this study 318 sera were obtained from healthy volunteer students of Tehran universities dormitories using ethnic stratified sampling. Then phenotyping was carried out by isoelectric focusing (IEF) with pharmalite pH= 4.2-4.9 in comparison with standard phenotypes.

  Results : From 318 normal sera, 201 had M1, 55M2, 41M3, 8MS, and 6 MZ phenotypes, 7 sera had other phenotypes.

  Conclusion : Allele frequency of M1, M2, M3, S, Z and other variants of AAT in the population of Iran were 0.6477, 0.1776, 0.1305, 0.0126, 0.0094 and 0.0220 respectively.

 

  Key words: AAT, IEF, Iran, Phenotyping

 

  *Corresponding author Tel: (021)8011001,Fax: (021)8013030, E-mail: Lotfi_ab@modares.ac.ir

  Journal of Rafsanjan University of Medical Sciences and Health Services, 2005, 4(1): 35-39

 

 

Keywords: AAT, IEF, Iran, Phenotyping
Full-Text [PDF 394 kb]   (2202 Downloads)    
Type of Study: Research | Subject: Biochemistry
Received: 2005/11/10

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