TY - JOUR T1 - The Analgesic Effect and Possible Mechanism of Colchicum Szovitsii Methanolic Extract in Mouse TT - اثر ضد دردی Ùˆ مکانیسم احتمالی عصاره متانولی گیاه سورنجان کرمانی در موش سوری JF - RUMS_JOURNAL JO - RUMS_JOURNAL VL - 4 IS - 1 UR - http://journal.rums.ac.ir/article-1-6-en.html Y1 - 2005 SP - 25 EP - 33 KW - Colchicum szovitsii KW - Hot-plate test KW - Formalin test KW - analgesia N2 -   The Analgesic Effect and Possible Mechanism of Colchicum Szovitsii Methanolic Extract in Mouse     MR. Heidari PhD1*, M. Vahedian MD2, S.Moamenzadeh Pharm.D3, MM. Hayatbakhsh Abbasi MD4   1- Associated Professor of Pharmacology, Dept. of Toxicology and Pharmacology, Faculty of Pharmacy, Neuroscience and Physciology Research Center,University of Medical Sciences, Kerman, Iran   2- Assistant Professor of General Surgery, University of Medical Sciences, Kerman, Iran   3- Pharmacist, Faculty of Pharmacy, University of Medical Sciences, Kerman, Iran   4- Assistant Professor of Internal Medicine, University of Medical Sciences, Kerman, Iran   Â  Background : Some of plants are used as analgesic in traditional medicine. The aim of this investigation was to evaluate the analgesic effects of colchicum szovitsii Fisch and C.A. Mey that has been used traditionally to relieve the pain.   Materials and Methods : The plant specimen was collected from Jupar, and then identified and nominated by a botanist. The dried bulbs of the plant was powdered and extracted by Percolated method and then concentrated by rotatory evaporator and oven. Different doses of methanolic extract of the plant was injected into male albino mice (20-25g) and its analgesic effect was evaluated by Hot-plate and formalin test.   Results : The results showed that all doses of extract, induce significant analgesia (p M3 ER -