RT - Journal Article T1 - Effect of Aqueous Extract of Descurainia Sophia on Castor Oil-Induced Diarrhea in Male Rat JF - RUMS_JOURNAL YR - 2013 JO - RUMS_JOURNAL VO - 12 IS - 2 UR - http://journal.rums.ac.ir/article-1-1694-en.html SP - 149 EP - 156 K1 - Diarrhea K1 - Descurainia sophia K1 - castor oil K1 - Rat AB -   Background and Objectives: Diarrhea is one of the worldwide health problems and one of the most common causes of childrens’ mortality. In the present experiment, effect of Descurainia sophia on castor oil-induced diarrhea was investigated.   Materials and Methods: In this experimentd study 24 male rats were randomly divided into 4 groups as follows: Descurainia sophia with doses of 400 and 600 mg/kg Diphenoxylate 0.5 mg/kg and control (vehicle). One hour after orally receiving the drugs or vehicle (normal saline 10 ml/kg), each animal was given castor oil (2 ml/rat) by an oro-gastric catheter. Then the rats were placed in a separate cage and observed for 5 h defecation to determine fecal quality, frequency, and weight. Data were analyzed by one-way ANOVA followed by Tukey test and p LA eng UL http://journal.rums.ac.ir/article-1-1694-en.html M3 ER -