AU - Vahidi, AR. AU - Dashti, MH. TI - The Effects of Caffeine on the Learning and Memory in Rats PT - JOURNAL ARTICLE TA - RUMS_JOURNAL JN - RUMS_JOURNAL VO - 3 VI - 3 IP - 3 4099 - http://journal.rums.ac.ir/article-1-43-en.html 4100 - http://journal.rums.ac.ir/article-1-43-en.pdf SO - RUMS_JOURNAL 3 AB  -   The Effects of Caffeine on the Learning and Memory in Rats     AR. Vahidi PharmD1* , MH. Dasht i PhD2     1 - Academic Member, Dept. of Pharmacology, Shahid Sadoughi University of Medical sciences, Yazd, IRAN   2. Assistant Professor, Dept. of Physiology, Shahid Sadoughi University of Medical sciences , Yazd, IRAN     Background: Caffeine as a methyl xanthine compound inhibits the breakdown of cyclic AMP, and causes an increase of the intracellular Ca+2 of different cells. It also may be involved in enhancement of learning and memory via this rout. In this study the effect of caffeine on learning and memory has been evaluated.   Materials and Methods: In this study the effects of different concentrations of caffeine (10, 20, 40, 80 mg/kg), on the learning and memory in male rats weighting 250-300 gr, were evaluated. The rats (30) were divided into 5 groups (4 test groups and 1 control group). The effects were assessed by using the one way active avoidance method. The test groups recieved different doses of caffeine in 3ml/kg normal saline (N.S), and the animals in the control group recived only N.S (3ml/kg) intraperitoneally, 30 minutes before each test.   Results: The data obtained from the test group was compared with the control group statistically. Our results indicated that caffeine affect on learning and memory dose depently. Using 10 mg/kg caffeine significantly increased the mean percentage of learning (p CP - IRAN IN - LG - eng PB - RUMS_JOURNAL PG - 180 PT - Research YR - 2004