%0 Journal Article %A Sepehri, G.R. %A Shamsi Meymandi, M. %A Mobasher, M. %A Mohammadi, R. %A Mohalati, A. %T Evaluation of the Effect of Gabapentin in the Enhances of the Analgesic Response to Morphine in Tail Flick of Male Rats %J Journal of Rafsanjan University of Medical Sciences %V 6 %N 1 %U http://journal.rums.ac.ir/article-1-283-en.html %R %D 2007 %K Key words: Gabapentin, Morphine, Co-administration, Acute pain, Antinociception, %X   Evaluation of the Effect of Gabapentin in the Enhances of the Analgesic Response to Morphine in Tail Flick of Male Rats     GR. Sepehri PhD [1] , M. Shamsi Meymandi MSc [2] , M. Mobasher [3] , R. Mohammadi [4] , A. Mohalati4     Received: 06/06/06 Sent for Revision: 01/11/06 Received Revised Manuscript: 15/03/07 Accepted: 29/04/07     Background and Objective: Opioids, as drug of choice in acute pain treatment, have many side effects including dependency. Therefore, the combinational therapy of other drugs accompanied with opioids could decrease the side effects, tolerance and opioid dependency. In this study the effect of gabapentin and morphine co-administration was evaluated in acute model of pain.   Materials and Methods: In this experimental study, the antinociceptive effect of gabapentin (30 or 90mg/kg, s.c.) and morphine (0.5, 1 and 3mg/kg, s.c.) alone or in combination with gabapentin were measured by Tail-flick test every 15 minuxtes up to 105 mins in intact adult male rats. Control rats received normal saline. Area Under Curve (AUC), as antinociceptive index, was calculated for each groups.   Results: Both gabapentin (90mg/kg) and morphine (1 and 3mg/kg) showed antinociceptive response as compared to controls (p %> http://journal.rums.ac.ir/article-1-283-en.pdf %P 7-14 %& 7 %! %9 Research %L A-10-176-2 %+ %G eng %@ 1735-3165 %[ 2007