TY - JOUR T1 - Evaluation the Affecting Factors in Lipid Peroxidation of Hemodialysis and Renal Transplanted Patients TT - ارزیابی عوامل مؤثر در پراکسیداسیون لیپیدی بیماران همودیالیزی و پیوندی JF - RUMS_JOURNAL JO - RUMS_JOURNAL VL - 6 IS - 1 UR - http://journal.rums.ac.ir/article-1-284-en.html Y1 - 2007 SP - 15 EP - 24 KW - Key words: Renal Transplant KW - Hemodialysis KW - Antioxidant KW - MDA KW - Magnesium KW - Lipid Profile N2 - Evaluation the Affecting Factors in Lipid Peroxidation of Hemodialysis and Renal Transplanted Patients GR. Moshtaghi Kashanian PhD , N. Rashtchi PhD , H. Ardakani MD , A. Ghorbani Haghjoo PhD2 Received: 23/07/05 Sent for Revision: 25/09/06 Received Revised Manuscript: 21/01/07 Accepted: 26/02/07 Background and Objective: Atherosclerosis is the most important cause of death in hemodialysis and renal transplanted patients while hyperlipidemia and lipid peroxidation are considered major risk factors of it. For this reason, the most important goals of therapy are elimination of risk factors of atherosclerosis among these patients. Since peroxidation of lipids are a multifactorial process and all factors have not been investigated in one study, we decided to investigate, serum concentrations of total cholesterol, triglycerides, cholesterol contained of high density lipoprotein (HDL-c), concentration of albumin, total magnesium (Mg), malondialdehyde (MDA) and total antioxidant of these patients and compare the results with corresponding data obtained for age and sex matched control group. Materials and Methods: In this cross-sectional study, 30 patients who were on hemodialysis and 30 renal transplanted patients were participated. Parameters mentioned above were measured using sera separated from the fasting blood collected from the patients. Evaluation of these parameters were done by following protocols provided by the manufactures of the kits, The results obtained were compared with the corresponding data of 30 healthy persons who served as control group. In addition, the cholesterol contained of low density lipoprotein (LDL-c) was calculated and plasma level of cyclosporine was measured for renal transplanted patients. Results: Evaluated data showed elevation in the serum levels of triglycerides (p M3 ER -