TY - JOUR T1 - The Application of 99mTc-Chitosan Microparticles in Lung Imaging of Mice: A Short Report TT - کاربرد میکرو ذرات چیتوزان – تکنسیوم-99 در تصویربرداری ریه موش: یک گزارش کوتاه JF - RUMS_JOURNAL JO - RUMS_JOURNAL VL - 13 IS - 10 UR - http://journal.rums.ac.ir/article-1-2236-en.html Y1 - 2015 SP - 1013 EP - 1018 KW - Chitosan KW - Lung perfusion scintigraphy KW - 99mTc-albumin macroaggregated KW - 99mTc N2 - Background and Objective: In nuclear medicine, lung perfusion scintigraphy is performed by radiolabeled particles, 99 mTc-albumin macroaggregated. Synthesizing of the particles has some difficulties. In order to resolve this problem, chitosan microparticles were used as an alternative choice.  Materials and Methods: The qualitative control tests including: the determining particles size, the labeling efficiency and stability in saline buffer and imaging studies in the mice were performed. Results: The size of particles was 90-110 micron. The labeling efficiency was 94±3%, the good stability in saline buffer and high accumulation of activity in mice lung were seen. Conclusion: The results showed that the 99mTc-chitosan microparticles may be considered as a promising radiopharmaceutical of lung perfusion scintigraphy that needs more investigations. Key words: Chitosan, Lung perfusion scintigraphy, 99mTc-albumin macroaggregated, 99mTc   Funding: This research was not funded by any university or organization. Conflict of Interest: Not declared. Ethical approval: This research was performed based on the Ethics Committee of Nuclear science and Technology institute, Helsinki ethic.   How to cite this article: Rasaneh S, Johari-Daha F. The Application of 99mTc-Chitosan Microparticles in Lung Imaging of Mice: A Short Report. J RafsanjanUniv Med Sci 2015 13(10): 1013-18. [Farsi] M3 ER -