AU - Ghalebi, S.R. AU - Hassanshahi, G.H. AU - Tabatabai Naini, S.A. AU - Esmaeili Nadimi, A. AU - Vazirinejad, R. AU - Rezaeian, M. AU - Shamsizadeh, A. AU - Akrami Mohajeri, F. TI - Evaluation of the Changes Pattern in Serum Levels of SDF-1α and IP-10 in Dogs Animal Model of Experimental Myocardial Infarction PT - JOURNAL ARTICLE TA - RUMS_JOURNAL JN - RUMS_JOURNAL VO - 11 VI - 2 IP - 2 4099 - http://journal.rums.ac.ir/article-1-1354-en.html 4100 - http://journal.rums.ac.ir/article-1-1354-en.pdf SO - RUMS_JOURNAL 2 AB  -   Background and Objectives : Since chemokines expression is one of the most inflammatory responses to injury in the myocardium , this project was aimed to find out the pattern of expression of SDF-1 and IP-10 in dog model of experimental ischemia to extend the results of this model to clinical applications.   Material and Methods: In this experimental study eighteen male dogs aged (6 - 12 months), were randomized in three groups. 1: infarction , Left Anterior Descending Coronary Artery (LAD) was ligated. 2: sham, received the same surgical procedure, excluding LAD ligation. 3: control, was held intact in the same condition. Blood samples were harvested 24 hours before operation, at the time of ligation, 2, 24 and 72 hours and 7 and 28 days after ligation in all groups and serum level of these chemokines was measured by means of ELISA test.   Results: In infarction group the serum level of IP-10 was significantly increased (p ≤ 0.05) at the 2, 24 and 72 hours after MI and reached at peak after 2 hours. In this group, serum level of SDF-1 α at 24 and 72 hours and 7 and 28 days after MI was significantly increased (p ≤ 0.05). The peak of increase was seen in the 72 hours after MI.   Conclusion: U pregulation of angiostatic factors, such as IP-10, in the first few hours following injury may inhibit premature angiogenesis. Suppression of IP-10 synthesis during the healing phase may allow formation of the wound neovessels, whereas high plasma levels of SDF-1 α are clinically associated with start of angiogenesis activities.   Key word: SDF-1α , IP-10, Experimental MI, Dog, Chemokine   Funding: This research was funded by both Rafsanjan University of Medical Sciences and Faculty of Veterinary Medicine of Shiraz University.   Conflict of interest : None declared.   Ethical approval: The Ethical Committee of Rafsanjan University of Medical Sciences approved the study.     How to cite this article : Ghalebi S.R, Hassanshahi G.H, Tabatabai Naini S.A, Esmaeili Nadimi A, Vazirinejad, Rezaeian M, Shamsizadeh A, Akrami Mohajeri F. Evaluation of the Changes Pattern in Serum Levels of SDF-1α and IP-10 in Dogs Animal Model of Experimental Myocardial Infarction. J Rafsanjan Univ Med scie 2012 11(2): 93-. [Farsi] CP - IRAN IN - LG - eng PB - RUMS_JOURNAL PG - 93 PT - Research YR - 2012