TY - JOUR T1 - The Effect of Hydroalcoholic Extract of Salvia Officinalis on Blood- Brain Barrier Permeability and Neuromotor Deficits in Male Rat Transient Ischemic Model TT - اثر عصاره هیدروالکلی گیاه مریم‌گلی (Salvia officinalis) بر میزان نفوذپذیری سد خونی-مغزی و اختلالات عصبی- حرکتی در مدل ایسکمی مغزی گذرا در موش صحرایی نر JF - RUMS_JOURNAL JO - RUMS_JOURNAL VL - 15 IS - 2 UR - http://journal.rums.ac.ir/article-1-2811-en.html Y1 - 2016 SP - 139 EP - 150 KW - Salvia officinalis KW - Transient ischemia KW - Blood brain barrier permeability KW - Neurologic deficits N2 - Background and Objectives: In the early stages of brain ischemia, the production of free radicals increases. Salvia officinalis is a rich source of antioxidant compounds. Therefore, in this study the effects of hydroalcoholic extract of Salvia officinalis on blood -brain barrier permeability and neurological deficits have been studied. Materials and Methods: In this experimental study 35 male Wistar rats were randomly divided into 5 groups of 7 rats. The control group received distilled water; three groups received hydroalcoholic extracts of Salvia officinalis, respectively with doses of 50, 75 and 100 mg/kg for, 3 weeks intraperitoneally; The sham group was not treated and was not induced bybrain ischemia. Thereafter, the first four groups underwent middle cerebral artery occlusion 2 hours after the last injection and were induced by focal cerebral ischemia model, then blood- brain barrier permeability, and neurologic deficits were investigated.. Data were analyzed using one-way ANOVA. Results: The hydroalcoholic extract of salvia could reduce permeability of the blood-brain barrier in three doses of 50 (10.68±0.54), 75 (5.87±0.41) ,and 100 mg/kg (5.19±0.49) compared with the control group (p=0.018, p<0.001 and p<0.001, respectively). Neurologic deficits reduced in the experimental groups of 75 and 100 mg/kg (p=0.017, p=0.002, respectively) compared with the control group. Conclusion: These results indicate that Salvia officinalis can make a guardianship in front of brain ischemia because it reduces blood- brain barrier permeability and neurologic deficits. Key words: Salvia officinalis, Transient ischemia, Blood brain barrier permeability, Neurologic deficits Funding: This research was funded by Islamic Azad University of Zanjan. Conflict of interest: None declared. Ethical approval: The Ethics Committee of Islamic Azad University of Zanjan approved the study. How to cite this article: Ghasemloo E, Rahnema M, Bigdeli MR. The Effect of Hydroalcoholic Extract of Salvia Officinalis on Blood- Brain Barrier Permeability and Neuromotor Deficits in Male Rat Transient Ischemic Model. J Rafsanjan Univ Med Sci 2016; 15(2): 129-38. [Farsi] M3 ER -