AU - Fahanik-Babaei, J. AU - Sadooghi, M. AU - Zardooz, H. AU - Sahraei, H. AU - . Bahadoran, H. AU - Saeidabadi, S. AU - Dashtnavard, H. AU - Jalili, C. AU - Ryahi, S. TI - Maternal Oral Morphine Consumption Delayes Olfactory Cortex Development in Wistar Rats During Embryonic Period: A Morphometric Study PT - JOURNAL ARTICLE TA - RUMS_JOURNAL JN - RUMS_JOURNAL VO - 9 VI - 1 IP - 1 4099 - http://journal.rums.ac.ir/article-1-698-en.html 4100 - http://journal.rums.ac.ir/article-1-698-en.pdf SO - RUMS_JOURNAL 1 AB  -   Background and Objectives: Previous studies have shown that morphine consumption during pregnancy may delay embryo development or cause abnormal nervous system function. This study focused on the effects of maternal morphine consumption on olfactory cortex development in Wistar rats.   Material and Methods: In this experimental study, 12 wistar rats (250-300g) were used. The experimental group received morphine solution (0.05 mg/ml) where as the control group received tap water. On the 19 th day the pregnant rats were killed by chloroform, and the embryos were removed surgically. The embryos were fixed in formalin 10% for 2 weeks. Then the weight of fixed embryos was calculated by a digital balance. In addition, animal sizes including Crump-Rump (C-R), Dorsal-Ventral (D-V), Frontal-Occipital (F-O), Abdominal Width, and Biparietal Axis length were measured by a caliper . Tissue processing, sectioning and staining (both hematoxylin and eosin (H&E) and silver nitrate staining) were then applied for the embryos. The sections were examined for olfactory cortex development by light microscope.   Results: Reductions in D-V lengths as well as embryonic weight was observed in the experimental group (p CP - IRAN IN - LG - eng PB - RUMS_JOURNAL PG - 3 PT - Research YR - 2010