TY - JOUR T1 - Effect of the Dorsal Raphe Nucleus Electrical Stimulation on Evoked Response of the IV Layers and V Barrel Cortical Neurons in Rat TT - اثر تحریک الکتریکی هسته رافه خلفی بر پاسخ برانگیخته نورون‌های لایه IV و V‌‌‌ قشر بارل (بشکه‌ای) در موش صحرایی JF - RUMS_JOURNAL JO - RUMS_JOURNAL VL - 6 IS - 3 UR - http://journal.rums.ac.ir/article-1-340-en.html Y1 - 2007 SP - 155 EP - 162 KW - Barrel cortex KW - Dorsal Raphe Nucleus KW - Rat KW - Electrical stimulation N2 - Effect of the Dorsal Raphe Nucleus Electrical Stimulation on Evoked Response of the IV Layers and V Barrel Cortical Neurons in Rat M.R Afarinesh MSc , V. Sheibani PhD , R. Farazifard MSc 1, M. Abasnegad PhD , A. Shamsi zadeh MSc Received: 17/09/06 Sent for Revision: 13/03/07 Received Revised Manuscript: 13/06/07 Accepted: 27/06/07 Background and Objective: Seretonergic pathway is one of the neuromodulatory mechanisms which mainly originates from dorsal raphe nucleus (DRN). In order to explore the role of serotonin on sensory processing, we investigated the effect of DRN stimulation on response properties of the IV layer and V neurons of whisker related area of rat somatosensory cortex. Materials and Methods: In this study twenty adult male Wistar rats (250-350gr) were used. DRN was stimulated at 0, 50, 100, 200 and 400ms before principal or adjacent whiskers deflection individually or in a condition test paradigm. For assessing the effect of DRN stimulation on inhibitory receptive field of barrel neurons, adjacent whisker was also deflected 20ms before principal whisker deflection. Results: DRN stimulation decreased the On response magnitude of layer V neurons to principal whisker deflection (p M3 ER -