RT - Journal Article T1 - Immunologic Alteration in Healty Cigarette Smoker Men JF - RUMS_JOURNAL YR - 2002 JO - RUMS_JOURNAL VO - 1 IS - 4 UR - http://journal.rums.ac.ir/article-1-3033-en.html SP - 216 EP - 224 K1 - Cigarette smoking K1 - Immunoglobulins K1 - White blood cells count K1 - Men AB - Background: The main function of the immune system is to defence against infections and killing the tumor cells. It has been reported that smoking reduces the resistance to infections and increases the incidence of cancers. The aim of this study was to assess selected indices of immunity, inhealthy  cigarette smoker men. Materials and Methods: Blood samples were collected from 68 healthy men, including, 32 subjects smoking for more than 5 years (case group), and 36 aged-matched men who never used to smoke (control group). The following parameters were studiedand compared in two groups: total and differential white blood cell (WBC) counts, serum concentration of immunoglobulins including: IgG, IgA, IgM and IgE, C3 and C4 complement components. Results: Decreased serum concentration of IgG, IgM and, IgA observed in smoker men compared to nonsmokers. Smokers had higher IgE concentration than non-smokers (522 IU/ml Vs 381 IU/ml P LA eng UL http://journal.rums.ac.ir/article-1-3033-en.html M3 ER -