fa گزارش یک مورد فنوتیپ نادر Rh--D: یک گزارش مورد هماتولوژي Hematology گزارش مورد Case Report <p class="MsoNormal" dir="RTL" style="margin-top: 0cm margin-right: 2.85pt margin-left: 7.1pt margin-bottom: 0.0001pt text-align: justify line-height: 125% "><b><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' ">چ</span></b><b><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' ">کیده</span></b><b><span lang="AR-SA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><o:p /></span></b></p> <p class="MsoNormal" dir="RTL" style="margin-top: 0cm margin-right: 2.85pt margin-left: 7.1pt margin-bottom: 0.0001pt text-align: justify line-height: 125% "><b><span lang="AR-SA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' ">زمینه و هدف:</span></b><span lang="AR-SA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "> </span><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' ">بعد از سیستم گروه خونی </span><span dir="LTR" style="line-height: 125% font-family: 'Times New Roman', serif ">ABO</span><span dir="RTL"></span><span dir="RTL"></span><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><span dir="RTL"></span><span dir="RTL"></span>، </span><span dir="LTR" style="line-height: 125% font-family: 'Times New Roman', serif ">Rh</span><span dir="RTL"></span><span dir="RTL"></span><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><span dir="RTL"></span><span dir="RTL"></span> یکی از مهمترین سیستم‌های گروه خونی است که سازگاری آن یکی از شروط اساسی در انتقال خون است. دو ژن </span><span dir="LTR" style="line-height: 125% font-family: 'Times New Roman', serif ">CE</span><span dir="RTL"></span><span dir="RTL"></span><span style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><span dir="RTL"></span><span dir="RTL"></span> <span lang="FA">و </span></span><span dir="LTR" style="line-height: 125% font-family: 'Times New Roman', serif ">D</span><span dir="RTL"></span><span dir="RTL"></span><span style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><span dir="RTL"></span><span dir="RTL"></span> <span lang="FA">واقع در کروموزوم شماره 1، پروتئین‌های سیستم </span></span><span dir="LTR" style="line-height: 125% font-family: 'Times New Roman', serif ">Rh</span><span dir="RTL"></span><span dir="RTL"></span><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><span dir="RTL"></span><span dir="RTL"></span> را کدگذاری می‌کنند. همچنین، آنتی‌ژن </span><span dir="LTR" style="line-height: 125% font-family: 'Times New Roman', serif ">D</span><span dir="RTL"></span><span dir="RTL"></span><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><span dir="RTL"></span><span dir="RTL"></span> عملکرد ایمونوژنیک دارد. در این گزارش به شرح موردی با فنوتیپ نادر </span><span dir="LTR" style="line-height: 125% font-family: 'Times New Roman', serif ">Rh--D</span><span dir="RTL"></span><span dir="RTL"></span><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><span dir="RTL"></span><span dir="RTL"></span>، می‌پردازیم. <o:p /></span></p> <p class="MsoNormal" dir="RTL" style="margin-top: 0cm margin-right: 2.85pt margin-left: 7.1pt margin-bottom: 0.0001pt text-align: justify line-height: 125% "><b><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' ">شرح مورد:</span></b><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "> آقای 49 ساله که در یک نوبت 2 واحد خون ⁺</span><span dir="LTR" style="line-height: 125% font-family: 'Times New Roman', serif ">O</span><span dir="RTL"></span><span dir="RTL"></span><span style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><span dir="RTL"></span><span dir="RTL"></span> <span lang="FA">دریافت کرده بود، در این گزارش مورد بررسی قرار گرفت. وی که برای جراحی پیوند کلیه در بیمارستان بستری بود، </span></span><span dir="LTR" style="line-height: 125% font-family: 'Times New Roman', serif ">Cross-Match</span><span dir="RTL"></span><span dir="RTL"></span><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><span dir="RTL"></span><span dir="RTL"></span> مکررا ناسازگار داشت. آزمایشات سرولوژیک بیمار نشان می‌داد وی یک فنوتیپ نادر </span><span dir="LTR" style="line-height: 125% font-family: 'Times New Roman', serif ">Rh--D </span><span dir="RTL"></span><span dir="RTL"></span><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><span dir="RTL"></span><span dir="RTL"></span>، با شیوع یک نفر در ده هزار نفر دارد.<o:p /></span></p> <p class="MsoNormal" dir="RTL" style="margin-top: 0cm margin-right: 2.85pt margin-left: 7.1pt margin-bottom: 0.0001pt text-align: justify line-height: 125% "><b><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' ">نتیجه‌گیری:</span></b><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "> با توجه به اهمیت آنتی‌ژن‌های سیستم </span><span dir="LTR" style="line-height: 125% font-family: 'Times New Roman', serif ">Rh</span><span dir="RTL"></span><span dir="RTL"></span><span style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><span dir="RTL"></span><span dir="RTL"></span> <span lang="FA">در بروز عوارض ناشی از تزریق خون، تعیین فنوتیپ گلبولی و تهیه خون اتولوگ به جلوگیری از وقوع عارضه کمک خواهد کرد.<o:p /></span></span></p> <p class="MsoNormal" dir="RTL" style="margin-top: 0cm margin-right: 2.85pt margin-left: 7.1pt margin-bottom: 0.0001pt text-align: justify line-height: 125% "><b><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' ">واژه‌های کلیدی:</span></b><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "> فنوتیپ </span><span dir="LTR" style="line-height: 125% font-family: 'Times New Roman', serif ">D</span><span dir="RTL"></span><span dir="RTL"></span><span lang="FA" style="font-size: 12pt line-height: 125% font-family: 'B Nazanin' "><span dir="RTL"></span><span dir="RTL"></span>، گروه خونی ارهاش، تزریق خون<span style="color: black "><o:p /></span></span></p> <p class="MsoNormal" style="text-align: justify line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-family: 'Times New Roman', serif ">Background and Objective</span></b><span style="font-family: 'Times New Roman', serif ">: Of all blood group systems, RH is one of the most important blood groups, which its compatibility is one of the essential principals of transfusion. Two genes (RhD and RhCE) locate on chromosome 1, and encode the Rh proteins. RhD is an immunogenic antigen. We describe a rare Rh phenotype D-- in this report.<o:p /></span></p> <p class="MsoNormal" style="text-align: justify line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-size: 12pt line-height: 150% font-family: 'Times New Roman', serif ">Case Report</span></b><span style="font-size: 12pt line-height: 150% font-family: 'Times New Roman', serif ">:</span><span style="font-family: 'Times New Roman', serif "> A forty- nine- year- old man, who received two O+ packed cells once time was studied in this report. He was admitted to hospital for kidney transplantation that reiterative mismatch cross matches were seen. Serologic tests of patient showed a rare Rh phenotype D-- with frequency of one in ten thousand.<o:p /></span></p> <p class="MsoNormal" style="text-align: justify line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-family: 'Times New Roman', serif ">Conclusion:</span></b><span style="font-family: 'Times New Roman', serif "> Considering the importance of Rh in blood transfusion complications, typing erythrocyte and preparing autologous blood will reduce transfusion complications.<o:p /></span></p> <p class="MsoNormal" style="text-align: justify line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-family: 'Times New Roman', serif ">Key words</span></b><span style="font-family: 'Times New Roman', serif ">: D--Phenotype, Transfusion, Rh blood group</span><span style="font-size: 12pt line-height: 150% font-family: 'Times New Roman', serif "><o:p /></span></p> <p class="MsoNormal" style="text-align: left line-height: 150% direction: ltr unicode-bidi: embed "><span style="font-family: 'Times New Roman', serif color: black "><!--stripped--> <!--stripped--></span></p> <p class="MsoNormal" style="text-align: left line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-family: 'Times New Roman', serif color: black ">How to cite this article</span></b><b><span style="font-family: 'Times New Roman', serif ">:</span></b><span style="font-size: 9pt line-height: 150% font-family: 'Times New Roman', serif "> Molahosseini Foomani F, Shams S.F, Arianpour Z. Reporting a Rare RH Phenotype D--<span class="hps">: A Case Report. </span><i><span style="color: black ">J RafsanjanUniv Med Sci</span></i><span style="color: black "> </span></span><span style="font-size: 9pt line-height: 150% font-family: 'Times New Roman', serif color: black ">2015 14(5):</span><span style="font-size: 9pt line-height: 150% font-family: 'Times New Roman', serif color: black "> 435-40. [Farsi]<o:p /></span></p> فنوتیپ D, گروه خونی ارهاش, تزریق خون D--Phenotype, Transfusion, Rh blood group 435 440 http://journal.rums.ac.ir/browse.php?a_code=A-10-2014-1&slc_lang=fa&sid=1 F. Molahosseini Foomani فرزاد ملاحسینی فومنی shams8869@yahoo.com 6900319475328460016651 6900319475328460016651 Yes S.F. Shams سیده فاطمه شمس 6900319475328460016652 6900319475328460016652 No Z. Arianpour زهرا آریان پور 6900319475328460016653 6900319475328460016653 No