Journal of Rafsanjan University of Medical Sciences
مجله دانشگاه علوم پزشکی رفسنجان
JRUMS
Medical Sciences
http://journal.rums.ac.ir
69
journal69
1735-3165
2008-7268
10.66224/jrums
fa
jalali
1402
2
1
gregorian
2023
5
1
22
1
online
1
fulltext
fa
بررسی اپیدمیولوژی لوسمی و لنفوم در کودکان زیر 15 سال مراجعهکننده به بیمارستان بعثت همدان از سال 1389 تا 1399: یک مطالعه توصیفی
Epidemiologic Study of Leukemia and Lymphoma in Children Younger than 15 Years Old Referring to Besat Hospital of Hamedan from 2010 to 2020:
A Descriptive Study
هماتولوژي
Hematology
پژوهشي
Research
<span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><a name="_Hlk113374001"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">زمینه و هدف: </span></span></span></b></a><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">سرطانها دومین عامل مرگومیر کودکان به شمار میروند. در این مطالعه تظاهرات بالینی لوسمی و لنفوم کودکان زیر 15 سال مراجعه کننده به بیمارستان بعثت همدان از سال 1389 تا 1399 مورد بررسی قرار گرفت.</span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">مواد و روشها:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin""> این مطالعه توصیفی-مقطعی، بهصورت گذشتهنگر بر روی 203 بیمار مبتلا به لوسمی و 77 بیمار مبتلا به لنفوم با سن کمتر از 15 سال انجام شد. دادههای مورد بررسی شامل سن، جنسیت، محل سکونت، تظاهرات و علائم بالینی اولیه، اولین یافتههای آزمایشگاهی و نوع لوسمی و لنفوم از پرونده بیماران استخراج شد. داده­ها با استفاده از آزمون­های </span></span></span>t<span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin""> مستقل و مجذور کای تجزیه­ و­ تحلیل شدند.</span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">یافتهها:</span></span></span></b> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">لوسمی و لنفوم در پسران فراوانی بیشتری را نشان داد. فراوانترین تظاهر بیماری در لوسمی تب یا ضعف 13 نفر (9/39 درصد) و علامت بیماری رنگپریدگی 77 نفر (9/37 درصد) </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">بود</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">. تفاوت معناداری بین دو نوع لوسمی از نظر میانگین سنی (005/0=</span></span></span>P<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">)، خون­ریزی (011/0=</span></span></span>P<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">) و لنفادنوپاتی (038/0=</span></span></span>P<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">) وجود داشت. فراوانی لنفوم هوچکین و غیر هوچکین به ترتیب 38 نفر (4/49 درصد) و 39 نفر (6/50 درصد) بود. لنفادنوپاتی سرویکال شایعترین نوع لنفادنوپاتی در بیماران بود (56 مورد، 7/72 درصد). درد گره لنفاوی و ادم شایعترین علامت بود (57 نفر، 74 درصد). ارتباط بین لنفادنوپاتی مدیاستینال با نوع لنفوم معنادار بود (018/0=</span></span></span>P<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">)، بهگونهای که لنفادنوپاتی مدیاستینال در لنفوم هوچکین فراوانی بیشتری داشت.</span></span></span><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin""></span></span></span></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">نتیجهگیری:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin""> تب شایعترین تظاهر بالینی و رنگپریدگی شایعترین علامت بالینی اولیه لوسمی و در کودکان مبتلا به لنفوم، درد گره لنفاوی مهمترین تظاهر بالینی می­باشد.</span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin"">واژه­های کلیدی:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin""> لوسمی، لوسمی لنفوبلاستیک، لوسمی میلوئیدی، لنفوم، کودکان</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:normal"><span style="font-family:"Times New Roman","serif""><span style="font-size:1.0pt"></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><a name="_Hlk114425361"><b><span style="font-size:9.5pt"><span style="line-height:150%">Background and Objectives:</span></span></b></a><span style="font-size:9.5pt"><span style="line-height:150%"> Cancers are the second cause of death among children. In this study, the clinical manifestations of leukemia and lymphoma in children under 15 years old, referring to Besat Hospital in Hamadan from 2010 to 2020, were investigated.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Materials and Methods:</span></span></b><span style="font-size:9.5pt"><span style="line-height:150%"> This descriptive cross-sectional study was conducted retrospectively on 203 patients with leukemia and 77 patients with lymphoma aged less than 15 years. Required data including age, gender, place of residence, initial clinical symptoms and manifestations, first laboratory findings, and type of leukemia and lymphoma were extracted from the patients’ records. Data were analyzed using independent t-test and chi-square test.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Results:</span></span></b><span style="font-size:9.5pt"><span style="line-height:150%"> Leukemia and lymphoma showed more frequency in boys. The most frequent manifestation of the disease in leukemia was fever or weakness in 13 people (39.9%), and the symptom of the disease was pallor in 77 people (37.9%). There was a significant difference between the two types of leukemia in terms of average age (p=0.005), bleeding (p=0.011), and lymphadenopathy (p=0.038). The frequency of Hodgkin's and non-Hodgkin's lymphoma was 38 (49.4%) and 39 (50.6%), respectively. Cervical lymphadenopathy was the most common type of lymphadenopathy in patients (56 cases, 72.7%). Lymph node pain and edema were the most common symptoms (57 people, 74%). There was a significant relationship between mediastinal lymphadenopathy and the type of lymphoma (p=0.018), so that mediastinal lymphadenopathy was more frequent in Hodgkin's lymphoma.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Conclusion:</span></span></b><span style="font-size:9.5pt"><span style="line-height:150%"> Fever is the most common clinical manifestation and pallor is the most common initial clinical symptom of leukemia, and in children with lymphoma, lymph node pain is the most important clinical manifestation.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Key words:</span></span></b><span style="font-size:9.5pt"><span style="line-height:150%"> Leukemia, Lymphoblastic leukemia, Myeloid leukemia, Lymphoma, Pediatrics</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Funding:</span></span></b><span style="font-size:9.5pt"><span style="line-height:150%"> This study did not have any funds.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Conflict of interest:</span></span></b><span style="font-size:9.5pt"><span style="line-height:150%"> None declared.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Ethical approval:</span></span></b><span style="font-size:9.5pt"><span style="line-height:150%"> The Ethics Committee of Hamadan University of Medical Sciences approved the study<b> </b>(IR.UMSHA.REC.1399.724).</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:4.0pt"><span style="line-height:150%"></span></span></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="line-height:140%">How to cite this article:</span></b> Mohebi Babak, Esfahani Hossein, Esna-Ashari Farzaneh.<b> </b><span style="line-height:140%">Epidemiologic Study of Leukemia and Lymphoma in Children Younger than 15 Years Old Referring to Besat Hospital of Hamedan from 2010 to 2020: A Descriptive Study</span><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">. </span></span><i><span style="font-size:9.0pt"><span style="line-height:140%">J Rafsanjan</span></span></i><span style="font-size:9.0pt"><span style="line-height:140%"> <i>Univ Med Sci</i> 2023; 22 (1): 53-64. [Farsi]</span></span> <b><span style="line-height:140%"></span></b></span></span></span></span></span><br>
لوسمی, لوسمی لنفوبلاستیک, لوسمی میلوئیدی, لنفوم, کودکان
Leukemia, Lymphoblastic leukemia, Myeloid leukemia, Lymphoma, Pediatrics
53
64
http://journal.rums.ac.ir/browse.php?a_code=A-10-6165-1&slc_lang=fa&sid=1
Babk
Mohebi
بابک
محبی
mohebi11aam@gmail.com
6900319475328460053442
6900319475328460053442
No
علوم پزشکی
Hossein
Esfahani
حسین
اصفهانی
hesfehani@yahoo.com hesfehani@yahoo.com
6900319475328460053443
6900319475328460053443
No
علوم پزشکی
Farzaneh
Esna-Ashari
فرزانه
اثنی عشری
esna_f@yahoo.com
6900319475328460053444
6900319475328460053444
Yes
علوم پزشکی