fa بررسی رعایت ملاحظات اخلاقی در طرح‌های تحقیقاتی حیوانات آزمایشگاهی در دانشگاه علوم پزشکی هرمزگان طی سال‌های 1397-1400: یک گزارش کوتاه علوم آزمايشگاهي علوم آزمايشگاهي كاربردي Applicable <span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><a name="_Hlk113374001"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">زمینه و هدف: </span></span></span></b></a><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">استفاده از معیارها و چارچوب&shy;های اخلاقی در تمامی پژوهش</span></span></span><i>‌</i><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">ها از اهمیت فراوانی برخوردار است. لذا هدف این مطالعه تعیین میزان رعایت ملاحظات اخلاقی در طرح</span></span></span><i>&shy;</i><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">های تحقیقاتی حیوانات آزمایشگاهی بود.</span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">مواد و روش&shy;ها:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> در این مطالعه توصیفی-مقطعی، تعداد 40 پروپوزال تحقیقاتی مربوط به حیوانات آزمایشگاهی بین سال&shy;های 1397-1400 دانشگاه علوم پزشکی هرمزگان جمع&shy;آوری و با استفاده از </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">فرم نظارت بر حیوانات آزمایشگاهی،</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> رعایت ملاحظات اخلاقی در آن‌ها مورد بررسی قرار گرفت. نتایج به صورت تعداد و درصد گزارش شده است. </span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">یافته‌ها:</span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">در 38 پروپوزال (95 درصد)، رفاه حیوانات در نظر گرفته شده بود. علاوه بر این، ملاحظات مربوط به ایمنی حیوانات و سلامتی حیوانات، اقدامات غیرجراحی و غیرتهاجمی، اقدامات بیهوشی و بی&shy;دردی، اقدامات جراحی و تهاجمی در 39 پروپوزال (5/97 درصد) رعایت شده بود. </span></span></span><i></i></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">نتیجه‌گیری:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> به نظر می‌رسد، در طرح‌های تحقیقاتی اصول اخلاقی کار با حیوان نیازمند توجه بیشتری است.</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">واژه</span></span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">‌های کلیدی</span></span></span></b><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> حیوانات آزمایشگاهی، مدل </span></span></span><i>&shy;</i><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">حیوانی</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">، </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">اخلاق، رفاه حیوانات</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <br> <span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span> <span style="font-size:10pt"><span style="line-height:135%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span dir="RTL" lang="AR-SA" style="font-size:5.0pt"><span style="line-height:135%"></span></span></b></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><a name="_Hlk114425361"><b><span style="line-height:150%">Background and Objectives:</span></b></a><span style="line-height:150%"> The use of criteria and ethical frameworks is critical in all research projects. &nbsp;Therefore, the purpose of this study was to determine the ethical considerations in laboratory animal research projects</span><span lang="EN-ZW" style="line-height:150%">.</span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="line-height:150%">Materials and Methods:</span></b><span style="line-height:150%"> In this descriptive cross-sectional study, 40 research proposals related to laboratory animals in Hormozgan University of Medical Sciences were collected during the years 2018-2021 and then, their compliance with ethical considerations was examined using the monitoring form of laboratory animals. The results were reported as numbers and percentages.</span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="line-height:150%">Results:</span></b><span style="line-height:150%"> The results indicated that animal welfare was considered in 38 proposals (95%). In addition, animal safety and health considerations, non-surgical and non-invasive </span><span lang="EN-ZW" style="line-height:150%">interventions</span><span style="line-height:150%">, anesthesia and analgesia measures, and surgical and invasive </span><span lang="EN-ZW" style="line-height:150%">interventions</span><span style="line-height:150%"> were mentioned in 39 proposals (97.5%). </span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="line-height:150%">Conclusion: </span></b><span style="line-height:150%">It seems that more attention to ethical principles is needed in working with<b> </b>animals in research projects.</span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-ZW" style="line-height:150%">Key words:</span></b><span lang="EN-ZW" style="line-height:150%"> Laboratory animals, Animal model, Ethics, Animal welfare</span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span lang="EN-ZW" style="line-height:150%"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-ZW" style="line-height:150%">Funding:</span></b><span lang="EN-ZW" style="line-height:150%"> This study was funded by Hormozgan Faculty of Para-medicine.</span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="line-height:150%">Conflict of interest:</span></b><span style="line-height:150%"> None declared.</span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="line-height:150%">Ethical approval:</span></b><span lang="EN-ZW" style="line-height:150%"> The Ethics Committee of Hormozgan University of Medical Sciences approved the study (IR.HUMS.REC.1400.382).</span><b><span lang="AR-SA" dir="RTL" style="line-height:150%"></span></b><b><span style="line-height:150%"></span></b><b><span style="line-height:150%"></span></b></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="line-height:150%"></span></b></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="line-height:150%">How to cite this article:</span></b><b> </b><span style="font-size:9.0pt"><span style="line-height:150%">Yazdani Damavandi Saber, Esmaeilzade Zeinab, Davari Dolatabadi</span></span> <span style="font-size:9.0pt"><span style="line-height:150%">Nasrin</span></span><span style="font-size:9.0pt"><span style="line-height:150%">.</span></span><span style="font-size:9.0pt"><span style="line-height:150%"> Survey of Compliance with Ethical Considerations in Laboratory Animal Research Projects in Hormozgan University of Medical Sciences During 2018-2021: A Short Report</span></span><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">. </span></span><i><span style="font-size:9.0pt"><span style="line-height:150%">J Rafsanjan</span></span></i><span style="font-size:9.0pt"><span style="line-height:150%"> <i>Univ Med Sci</i> 2023; 22 (3): 293-300. [Farsi]</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:8.0pt"><span style="line-height:150%"></span></span></b></span></span></span></span></span><br> <br> <span style="line-height:115%"><span style="font-size:12.0pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif"></span></span></span></span> حیوانات آزمایشگاهی, مدل ­حیوانی, اخلاق, رفاه حیوانات Laboratory animals, Animal model, Ethics, Animal welfare 293 300 http://journal.rums.ac.ir/browse.php?a_code=A-10-6178-1&slc_lang=fa&sid=1 Saber Yazdani Damavandi صابر یزدانی دماوندی yazdani.saberhit1@gmail.com 6900319475328460054104 6900319475328460054104 No Hormozgan University of Medical sciences دانشگاه علوم پزشکی هرمزگان Zeinab Esmaeilzadeh زینب اسماعیل زاده zeinab73e@gmail.com 6900319475328460054105 6900319475328460054105 No Hormozgan University of Medical sciences دانشگاه علوم پزشکی هرمزگان Nasrin Davari Dolatabadi نسرین داوری دولت آبادی davarinn@gmail.com 6900319475328460054106 6900319475328460054106 Yes Hormozgan University of Medical sciences دانشگاه علوم پزشکی هرمزگان