Journal of Rafsanjan University of Medical Sciences
مجله دانشگاه علوم پزشکی رفسنجان
JRUMS
Medical Sciences
http://journal.rums.ac.ir
69
journal69
1735-3165
2008-7268
10.66224/jrums
fa
jalali
1403
12
1
gregorian
2025
3
1
23
11
online
1
fulltext
fa
اختلال حافظه و آسیب هیپوکامپ پس از مصرف مکرر مورفین: یک نقطه نظر
Memory Impairment and Hippocampal Damage after Repeated Morphine Use:
A Point of View
فيزيولوژي
Physiology
پژوهشي
Research
<span style="font-size:10pt"><span style="line-height:135%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><span lang="FA" style="font-size:12.0pt"><span style="line-height:135%"><span style="font-family:"B Nazanin"">هیپوکامپ، به عنوان یکی از ساختارهای کلیدی مغز، نقش بسیار مهمی در فرآیندهای شناختی مانند شکلگیری حافظه و ذخیره اطلاعات ایفاء میکند. تجویز مورفین میتواند تغییر قابلتوجهی در ساختار و عملکرد هیپوکامپ ایجاد کند، که این امر نگرانیهایی را در مورد اثرات طولانیمدت آن بر سلامت شناختی به وجود آورده است. مورفین عمدتاً از طریق فعالسازی گیرندههای مواد افیونی در سیستم عصبی مرکزی عمل میکند و این فعالسازی میتواند منجر به استرس اکسیداتیو، التهاب عصبی و آپوپتوز نورونها شود. تغییرات در چگالی و مورفولوژی دندریتیک نورونهای هیپوکامپ به کاهش انعطافپذیری سیناپسها منجر میشود که میتواند عملکردهای شناختی مانند یادگیری و حافظه را مختل کند. اثرات تجمعی استرس اکسیداتیو، التهاب و تغییرات سیناپسی به اختلالات شناختی مانند نقصهای حافظه فضایی و تواناییهای یادگیری منجر میشود. بنابراین، درک مکانیسمهای زیرساختی اثرات نوروتوکسیک مورفین بر هیپوکامپ برای توسعه مداخلات درمانی ضروری است. بهترین راهکار درمانی، آگاه ساختن افراد و پیشگیری است.</span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:135%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:135%"><span style="font-family:"B Nazanin"">واژههای کلیدی:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:135%"><span style="font-family:"B Nazanin""> مورفین، هیپوکامپ، حافظه</span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><a name="_Hlk114425361"><span style="font-size:9.0pt"><span style="line-height:150%">The hippocampus, as one of the key structures of the brain, plays a crucial role in cognitive processes such as memory formation and information storage. Morphine administration can cause significant changes in the structure and function of the hippocampus, which has raised concerns about its long-term effects on cognitive health. Morphine acts mainly through the activation of opioid receptors in the central nervous system, and this activation can lead to oxidative stress, neuroinflammation, and neuronal apoptosis. Changes in dendritic density and morphology of hippocampal neurons lead to reduced synaptic plasticity, which in turn can impair cognitive functions such as learning and memory. The cumulative effects of oxidative stress, inflammation, and synaptic changes lead to cognitive impairments such as deficits in spatial memory and learning abilities. Therefore, understanding the underlying mechanisms of morphine's neurotoxic effects on the hippocampus is essential for the development of therapeutic interventions. The best treatment solution is to make people aware and prevent it.</span></span></a></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:9.0pt"><span style="line-height:150%">Key words: </span></span></b><span style="font-size:9.0pt"><span style="line-height:150%">Morphine, Hippocampus, Memory<b> </b></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:9.0pt"><span style="line-height:150%"></span></span></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:9.0pt"><span style="line-height:150%">Funding:</span></span></b><span style="font-size:9.0pt"><span style="line-height:150%"> None.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:9.0pt"><span style="line-height:150%">Conflict of interest:</span></span></b><span style="font-size:9.0pt"><span style="line-height:150%"> Not applicable.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span style="font-size:9.0pt"><span style="line-height:150%">Ethical considerations:</span></span></b><span style="font-size:9.0pt"><span style="line-height:150%"> Not applicable.</span></span><span dir="RTL" lang="FA" style="font-size:9.0pt"><span style="line-height:150%"></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">Authors’ contributions:</span></span></b><b><span style="font-size:9.0pt"><span style="line-height:150%"></span></span></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">- Conceptualization:</span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%"> Ayat Kaeidi</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">- Methodology:</span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%"> Ayat Kaeidi</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">- Data </span></span></b><b><span style="font-size:9.0pt"><span style="line-height:150%">collection</span></span></b><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">:</span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%"> Ayat Kaeidi</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">- Formal analysis:</span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%"> Ayat Kaeidi</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">- Supervision: </span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">Ayat Kaeidi</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">- Project administration:</span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%"> Ayat Kaeidi</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">- Writing - original draft:</span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%"> Ayat Kaeidi</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">- Writing - </span></span></b><b><span style="font-size:9.0pt"><span style="line-height:150%">review & </span></span></b><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">editing:</span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%"> Ayat Kaeidi</span></span><span class="MsoHyperlink" style="color:#0563c1"><span style="text-decoration:underline"></span></span></span></span></span></span></span><br>
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" style="position:absolute; left:0; text-align:left; margin-top:2px; width:494.7pt; height:35.7pt; z-index:-251665920; v-text-anchor:top"> <w:wrap anchorx="margin"> </w:wrap></v:roundrect><b><span dir="RTL" lang="FA" style="font-size:2.0pt"><span style="line-height:150%"><span style="font-family:Nazanin"></span></span></span></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><b> </b><b><span style="line-height:150%">Citation:</span></b><span style="font-size:9.0pt"><span style="line-height:150%"> Kaeidi</span></span> A. <span style="font-size:9.0pt"><span style="line-height:150%">Memory Impairment and Hippocampal Damage After Repeated Morphine Use: A Point of View</span></span><span lang="EN" style="font-size:9.0pt"><span style="line-height:150%">. </span></span><i><span style="font-size:9.0pt"><span style="line-height:150%">J Rafsanjan</span></span></i><span style="font-size:9.0pt"><span style="line-height:150%"> <i>Univ Med Sci</i> 2025; 23 (11): 1037-43. [Farsi]</span></span> <span style="font-size:9.0pt"><span style="line-height:150%"></span></span></span></span></span></span></span><br>
مورفین, هیپوکامپ, حافظه
1037
1043
http://journal.rums.ac.ir/browse.php?a_code=A-10-3101-3&slc_lang=fa&sid=1
Ayat
Kaeidi
آیت
کائیدی
a.kayedi@gmail.com
6900319475328460059937
6900319475328460059937
Yes
Rafsanjan University of Medical Sciences
دانشگاه علوم پزشکی رفسنجان