Journal of Rafsanjan University of Medical Sciences
مجله دانشگاه علوم پزشکی رفسنجان
JRUMS
Medical Sciences
http://journal.rums.ac.ir
69
journal69
1735-3165
2008-7268
10.66224/jrums
fa
jalali
1404
9
1
gregorian
2025
12
1
24
9
online
1
fulltext
fa
تأثیر نانولیپوزوم کورکومین بر ترمیم زخم پوستی در موشهای نر نژاد BALB/c: یک مطالعه تجربی
The Effect of Curcumin Nanoliposomes on Skin Wound Healing in BALB/c Mice: An Experimental Study
علوم تشريح
علوم تشريح
پژوهشي
Research
<span style="font-size:10pt"><span style="line-height:110%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:11.5pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">چکیده</span></span></span></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">زمینه و هدف:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> ترمیم زخم فرآیندی پیچیده، شامل مراحل هموستاز، التهاب، تکثیر و بازسازی بافت است. کورکومین بهعنوان ترکیبی طبیعی دارای خواص ضدالتهابی و </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">آنتیاکسیدانی شناخته شده است، اما زیستفراهمی پایین آن، کاربرد موضعیاش را محدود کرده است. این مطالعه با هدف تعیین تأثیر نانولیپوزوم کورکومین بر روند ترمیم زخم پوستی در موشهای نر نژاد </span></span></span>BALB/c<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> انجام شد.</span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">مواد و روشها:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> در این مطالعه تجربی، </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">۴۸</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> سر موش نر </span></span></span>BALB/c<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> (</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">5/2</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> ماهه) بهطور تصادفی در چهار گروه آزمایش (دریافتکننده کرم نانولیپوزوم کورکومین)، کنترل مثبت (کرم نیتروفورازون)، کنترل منفی (کرم دارونما)، و گروه شم (بدون درمان) تقسیم شدند. پس از ایجاد زخم در ناحیه پشتی حیوانات، درمانها به­صورت موضعی اعمال شد. نمونهبرداری بافتی در روزهای </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">۴</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">، </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">۷</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">، </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">۱۰</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> و </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">۱۴</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> انجام و ارزیابیهای بافتشناسی با رنگآمیزی </span></span></span>H&E<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> و </span></span></span>Masson Trichrome<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> صورت گرفت. دادهها با استفاده آنالیز واریانس یکطرفه و آزمون تعقیبی </span></span></span>Tukey<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> تجزیه و تحلیل شدند.</span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">یافتهها:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> گروه آزمایش در روزهای </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">۴</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">، </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">۷</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> و </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">۱۰</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> کاهش معنیداری در تعداد سلولهای التهابی <a name="_Hlk210208983">نسبت به گروههای کنترل منفی و شم</a> نشان داد (</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">001/0></span></span></span>P<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">). همچنین، در این گروه افزایش قابلتوجهی در تعداد فیبروبلاستها، میزان سنتز رشتههای کلاژن، وسعت بافت گرانوله و بازسازی اپیتلیومی نسبت به گروههای کنترلمنفی و شم مشاهده شد (</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">001/0></span></span></span>P<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">). روند بهبودی در گروه آزمایش نسبت به گروه کنترل مثبت تقریباً برابر و در برخی موارد اندکی بهتر بود.</span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">نتیجهگیری:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> مطالعه حاضر نشان داد که نانولیپوزوم کورکومین میتواند با کاهش التهاب و تحریک فاز تکثیر، نقش مؤثری در بهبود زخمهای پوستی در مدل حیوانی موش</span></span></span> BALB/c <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">ایفاء کند.</span></span></span></span></span></span></span></span><br>
<b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">واژههای کلیدی:</span></span></span></b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> نانولیپوزوم، کورکومین، ترمیم زخم، موش </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">BALB/c</span></span></span>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><a name="_Hlk114425361"><b><span style="font-size:9.0pt"><span style="line-height:140%">Background and Objectives: </span></span></b></a><span style="font-size:9.0pt"><span style="line-height:140%">Wound healing is a complex process involving hemostasis, inflammation, proliferation, and tissue remodeling. Curcumin is known as a natural compound with anti-inflammatory and antioxidant properties, but its low bioavailability has limited its topical application.</span></span> <span style="font-size:9.0pt"><span style="line-height:140%">This study aimed to determine the effect of curcumin nanoliposomes on the healing process of skin wounds in male BALB/c mice.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">Materials and Methods:</span></span></b><span style="font-size:9.0pt"><span style="line-height:140%"> in this experimental study, 48 male BALB/c mice (2.5 months old) were randomly assigned to four groups:</span></span> <span style="font-size:9.0pt"><span style="line-height:140%">experimental</span></span> <span style="font-size:9.0pt"><span style="line-height:140%">(treated with curcumin nanoliposome cream), positive control (nitrofurazone cream), negative control (placebo cream), and sham (no treatment). After wound induction on the dorsal region, treatments were topically applied. Tissue sampling was collected on days 4, 7, 10, and 14, and histological evaluations were performed using H&E and Masson’s trichrome staining. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test</span></span><span dir="RTL" lang="FA" style="font-size:9.0pt"><span style="line-height:140%">.</span></span><span style="font-size:9.0pt"><span style="line-height:140%"></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">Results:</span></span></b><span style="font-size:9.0pt"><span style="line-height:140%"> The experimental group showed a significant reduction in inflammatory cells on days 4, 7, and 10 compared to the negative control and sham groups (p<0.001). This group also showed increased fibroblasts, collagen fiber synthesis, granulation tissue formation, and epithelial regeneration compared to the negative control and sham groups (p<0.001). Healing in the experimental group was comparable to, and in some parameters slightly better than, the positive control group.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">Conclusion:</span></span></b><span style="font-size:9.0pt"><span style="line-height:140%"> The current study indicated that curcumin nanoliposomes can effectively promote wound healing in BALB/c mice by reducing inflammation and stimulating the proliferative phase.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">Keywords:</span></span></b><span style="font-size:9.0pt"><span style="line-height:140%"> Nanoliposome, Curcumin, Wound healing, BALB/c mice</span></span><span dir="RTL" lang="FA" style="font-size:9.0pt"><span style="line-height:140%"></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%"></span></span></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">Funding: </span></span></b><span style="font-size:9.0pt"><span style="line-height:140%">This study was funded by Birjand University of Medical Sciences.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">Conflict of interest: </span></span></b><span style="font-size:9.0pt"><span style="line-height:140%">None declared.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">Ethical considerations: </span></span></b><span style="font-size:9.0pt"><span style="line-height:140%">The Ethics Committee of Birjand University of Medical Sciences approved the study (IR.BUMS.REC.1398.412).</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">Authors’ contributions:</span></span></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">- Conceptualization:</span></span></b><span style="font-size:9.0pt"><span style="line-height:140%"> Maryam Taleb Rouhi, Mohammad Afshar Ghoochani </span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">- Methodology:</span></span></b><span style="font-size:9.0pt"><span style="line-height:140%"> Maryam Taleb Rouhi, Mohammad Afshar Ghoochani</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">- Data collection:</span></span></b><span style="font-size:9.0pt"><span style="line-height:140%"> Maryam Taleb Rouhi, Ali Sanjarani</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">- Formal analysis:</span></span></b><span style="font-size:9.0pt"><span style="line-height:140%"> Mohammad Afshar Ghoochani, Mohammad Hossein Habibollahi</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">- Supervision:</span></span></b><span style="font-size:9.0pt"><span style="line-height:140%"> Mohammad Hossein Habibollahi</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">- Project administration:</span></span></b><span style="font-size:9.0pt"><span style="line-height:140%"> Mohammad Afshar Ghoochani, Mohammad Hossein Habibollahi</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">- Writing – original draft:</span></span></b><span style="font-size:9.0pt"><span style="line-height:140%"> Maryam Taleb Rouhi, Ali Sanjarani</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">- Writing – review & editing:</span></span></b><span style="font-size:9.0pt"><span style="line-height:140%"> Mohammad Hossein Habibollahi</span></span><span style="font-size:9.0pt"><span style="line-height:140%"></span></span></span></span></span></span></span><br>
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<div><span style="font-size:10pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:8.0pt"><span style="line-height:150%">Citation:</span></span></b> <span style="font-size:8.0pt"><span style="line-height:150%">Taleb Rouhi M, Afshar Ghoochani M, Sanjarani A, Habibollahi MH. The Effect of Curcumin Nanoliposomes on Skin Wound Healing in BALB/c Mice: A Experimental Study</span></span><span style="font-size:8.0pt"><span style="line-height:150%">. <i>J Rafsanjan</i> <i>Univ Med Sci</i> 2025; 24 (9): 775-88. [Farsi]</span></span><span style="font-size:8.0pt"><span style="line-height:150%"></span></span></span></span></span></div>
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نانولیپوزوم, کورکومین, ترمیم زخم, موش BALB/c
Nanoliposome, Curcumin, Wound healing, BALB/c mice
775
778
http://journal.rums.ac.ir/browse.php?a_code=A-10-5896-2&slc_lang=fa&sid=1
Maryam
Taleb Rouhi
مریم
طالب روحی
ma.talebrohi@gmail.com
6900319475328460061952
6900319475328460061952
No
دانشگاه علوم پزشکی بیرجند
Mohammad
Afshar Ghoochani
محمد
افشار قوچانی
afshar-md@yahoo.com
6900319475328460061953
6900319475328460061953
No
دانشگاه علوم پزشکی بیرجند
Ali
Sanjarani
علی
سنجرانی
afshar_md@yahoo.com
6900319475328460061954
6900319475328460061954
No
کارشناس ارشد سمشناسی پزشکی، تهران
Mohammad Hossein
Habibollahi
محمدحسین
حبیب الهی
mh.habibollahi@iau.ac.ir
6900319475328460061955
6900319475328460061955
Yes
دانشگاه آراد اسلامی واحد زاهدان