Journal of Rafsanjan University of Medical Sciences
Journal of Rafsanjan University of Medical Sciences
1735-3165
2008-7268
2
2
2003
6
1
Serum HDL2-C Evaluation in Patients with Coronary Heart Disease
74
81
FA
S.
Hasannia
Y
F.
Mir Blook
N
A.S.
Lotfi
N
A.
Mohsenifar
N
M.
Mahmoodi
N
CHD, HDL, Angiography, Lipids
http://journal.rums.ac.ir/article-1-66-en.html
http://journal.rums.ac.ir/article-1-66-en.pdf
Journal of Rafsanjan University of Medical Sciences
Journal of Rafsanjan University of Medical Sciences
1735-3165
2008-7268
2
2
2003
6
1
Modulation of Cell-Mediated Immune Response Following Burn Injury in an Animal Model of Balb/c Mice.
94
101
FA
A.
Jafarzadeh
Y
Z.
Mohammad Hassan
N
M.
Ebtekar
N
S.
Mohaghegh Hazrati
N
Background: Infection is the major cause of death in thermal injury patients. Severe suppression of the immune system is the major cause of infection following burn injury. The aim of this study was to modulate the cell-mediated immune response by the use of cimetidine and pyrimethamine in an animal burn model.
Materials and Methods: Male Balb/c mice were anesthetized, and given a 10% total body surface area full-thickness burn. Then the delayed type hypersensitivity (DTH) to sheep red blood cell (SRBC) and the effects of different doses of immunomodulators (cimetidine 5,10 and 15 mg/kg and pyrimethamine 2.5,5,10 mg/kg) on this response were quantitated ten days after the burn.
Results: The marked suppression of DTH was observed ten days after burn,s trauma. Cimetidine (at doses of 10 and 15 mg/kg) and pyrimethamine (at doses of 5 and 10 mg/kg) significantly augmented DTH response after thermal injury. Cimetidine and pyrimethamine did not exhibit any effect on DTH response at doses of 5 mg/kg and 2.5 mg/kg respectively.
Conclusion: These results indicated that severe suppression of DTH responses occured after burn injury. Cimetidine and pyrimethamine prevented inhibition of DTH response following thermal trauma.
Keywords: Burn, Delayed type hypersensitivity, Cimetidine, Pyrimethamine, Immunomodulation.
* Corresponding author tel: (391) 5234003-5
Journal of Rafsanjan University of Medical Sciences and Health Services, 2002, 2(2): 94-101.
Burn, Delayed type hypersensitivity, Cimetidine, Pyrimethamine, Immunomodulation
http://journal.rums.ac.ir/article-1-3035-en.html
http://journal.rums.ac.ir/article-1-3035-en.pdf
Journal of Rafsanjan University of Medical Sciences
Journal of Rafsanjan University of Medical Sciences
1735-3165
2008-7268
2
2
2003
6
1
Prevalence of Intestinal Parasite Infections in the Day Care Centers of Bam
102
111
FA
R.
Ahmad-rajabi
Y
F.
Varzandeh
N
M.
Arab
N
A.
Abbaszadeh
N
Intestinal parasites, Children, Day Care Centers , Bam
http://journal.rums.ac.ir/article-1-68-en.html
http://journal.rums.ac.ir/article-1-68-en.pdf
Journal of Rafsanjan University of Medical Sciences
Journal of Rafsanjan University of Medical Sciences
1735-3165
2008-7268
2
2
2003
6
1
Prospective Study of Etiologies of Acute Abdominal Syndrome in Patients Admitted to Ali Ibn Abitaleb Hospital of Rafsanjan
112
118
FA
M.
Rezai Nasab
Y
Acute abdominal pain., Appendicitis, Non specific abdominal pain. Renal colic, Ovarian
http://journal.rums.ac.ir/article-1-69-en.html
http://journal.rums.ac.ir/article-1-69-en.pdf
Journal of Rafsanjan University of Medical Sciences
Journal of Rafsanjan University of Medical Sciences
1735-3165
2008-7268
2
2
2003
6
1
Congental Glucose- Galactose Malabsorption a Rare Cause of Diarrhea in Infancy Period: Report of Two Cases
119
123
EN
R.
Vakili
Y
SH.
Rasouli
N
Glucose - Galactose malabsorption, Diarrhea, failure to thrive
http://journal.rums.ac.ir/article-1-70-en.html
http://journal.rums.ac.ir/article-1-70-en.pdf