Journal of Rafsanjan University of Medical Sciences

Background and Objectives: In the early stages of brain ischemia, the production of free radicals increases. Salvia officinalis is a rich source of antioxidant compounds. Therefore, in this study the effects of hydroalcoholic extract of Salvia officinalis on blood -brain barrier permeability and neurological deficits have been studied.

Materials and Methods: In this experimental study 35 male Wistar rats were randomly divided into 5 groups of 7 rats. The control group received distilled water; three groups received hydroalcoholic extracts of Salvia officinalis, respectively with doses of 50, 75 and 100 mg/kg for, 3 weeks intraperitoneally; The sham group was not treated and was not induced  bybrain ischemia. Thereafter, the first four groups underwent middle cerebral artery occlusion 2 hours after the last injection and were induced by focal cerebral ischemia model, then blood- brain barrier permeability, and neurologic deficits were investigated.. Data were analyzed using one-way ANOVA.

Results: The hydroalcoholic extract of salvia could reduce permeability of the blood-brain barrier in three doses of 50 (10.68±0.54), 75 (5.87±0.41) ,and 100 mg/kg (5.19±0.49) compared with the control group (p=0.018, p<0.001 and p<0.001, respectively). Neurologic deficits reduced in the experimental groups of 75 and 100 mg/kg (p=0.017, p=0.002, respectively) compared with the control group.

Conclusion: These results indicate that Salvia officinalis can make a guardianship in front of brain ischemia because it reduces blood- brain barrier permeability and neurologic deficits.

Key words: Salvia officinalis, Transient ischemia, Blood brain barrier permeability, Neurologic deficits

Funding: This research was funded by Islamic Azad University of Zanjan.

Conflict of interest: None declared.

Ethical approval: The Ethics Committee of Islamic Azad University of Zanjan approved the study.

How to cite this article: Ghasemloo E, Rahnema M, Bigdeli MR. The Effect of Hydroalcoholic Extract of Salvia Officinalis on Blood- Brain Barrier Permeability and Neuromotor Deficits in Male Rat Transient Ischemic Model. J Rafsanjan Univ Med Sci 2016; 15(2): 129-38. [Farsi]