Volume 16, Issue 7 (10-2017)
JRUMS 2017, 16(7): 633-644 |
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Arbabi S, Bayrami A, Sheidaii P. An Investigation of the Toxicity of Zinc Oxide and Titanium Oxide Nanoparticles on Some Liver Enzymes in Male Mice
. JRUMS 2017; 16 (7) :633-644
URL: http://journal.rums.ac.ir/article-1-3690-en.html
URL: http://journal.rums.ac.ir/article-1-3690-en.html
univesity of mohaghegh ardebili
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An Investigation of the Toxicity of Zinc Oxide and Titanium Oxide Nanoparticles on Some Liver Enzymes in Male Mice
S. Arbabi[1], A. Bayrami[2], P. Sheidaii1
Received: 28/02/2017 Sent for Revision: 06/05/2017 Received Revised Manuscript: 20/09/2017 Accepted: 23/09/2017
Background and Objectives: The advancement of nanotechnology has made it more important to study the destructive effects of nano-materials on organisms. Titanium dioxide and zinc oxide nanoparticles can enter the body in different ways and cause damage to the liver and other organs of the body. The purpose of this study was to evaluate the effects of zinc oxide and titanium dioxide nanoparticles on some liver enzymes and tissue in male rats.
Materials and Methods: In this experimental study, 70 adult male mice were divided into ten groups including one control and nine experimental groups. The mice in the experimental groups orally received zinc oxide and titanium oxide nanoparticles with doses of 50, 100, and 300 mg/kg. The experiment lasted for 14 days, then on the fifteenth day, blood samples were collected. Liver tissues and some liver enzymes (Alanine aminotransferase, Alkaline phosphatase, and Aspartate aminotransferase) were analayzed. The data were analyzed using one way ANOVA and Duncan post hoc test with respect to normal distribution.
Results: The results showed that zinc oxide and titanium dioxide nanoparticles at concentrations of 100 and 300 mg / kg, and the combination of these two nanoparticles at concentrations of 50, 100, and 300 mg caused a significant change in the activity of liver enzymes (alanine aminotransferase, alkaline phosphatase, and aspartate aminotransferase) that was more than the control group (p<0.05).
Conclusion: The results showed that zinc oxide and titanium dioxide nanoparticles at different doses may increase serum levels of enzymes due to liver degeneration and increased leakage of liver enzymes. However, further studies are proposed to predict the effects of this substance and to safely use these nanoparticles.
Key words: Liver enzyme, Titanium oxide nanoparticles, Zinc oxide nanoparticles, Mice
Funding: This research was funded by University of Mohaghegh Ardabili.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of University of Mohaghegh Ardabili approved the study.
How to cite this article: Arbabi S, Bayrami A, Sheidaii P. An Investigation of the Toxicity of Zinc Oxide and Titanium Oxide Nanoparticles on Some Liver Enzymes in Male Mice. J Rafsanjan Univ Med Sci 2017; 16(7): 633-44. [Farsi]
[1]- MSc Student in Animal Biology, Faculty of Basic Sciences, University of Mohagegh Ardabili, Ardabili, Iran
S. Arbabi[1], A. Bayrami[2], P. Sheidaii1
Received: 28/02/2017 Sent for Revision: 06/05/2017 Received Revised Manuscript: 20/09/2017 Accepted: 23/09/2017
Background and Objectives: The advancement of nanotechnology has made it more important to study the destructive effects of nano-materials on organisms. Titanium dioxide and zinc oxide nanoparticles can enter the body in different ways and cause damage to the liver and other organs of the body. The purpose of this study was to evaluate the effects of zinc oxide and titanium dioxide nanoparticles on some liver enzymes and tissue in male rats.
Materials and Methods: In this experimental study, 70 adult male mice were divided into ten groups including one control and nine experimental groups. The mice in the experimental groups orally received zinc oxide and titanium oxide nanoparticles with doses of 50, 100, and 300 mg/kg. The experiment lasted for 14 days, then on the fifteenth day, blood samples were collected. Liver tissues and some liver enzymes (Alanine aminotransferase, Alkaline phosphatase, and Aspartate aminotransferase) were analayzed. The data were analyzed using one way ANOVA and Duncan post hoc test with respect to normal distribution.
Results: The results showed that zinc oxide and titanium dioxide nanoparticles at concentrations of 100 and 300 mg / kg, and the combination of these two nanoparticles at concentrations of 50, 100, and 300 mg caused a significant change in the activity of liver enzymes (alanine aminotransferase, alkaline phosphatase, and aspartate aminotransferase) that was more than the control group (p<0.05).
Conclusion: The results showed that zinc oxide and titanium dioxide nanoparticles at different doses may increase serum levels of enzymes due to liver degeneration and increased leakage of liver enzymes. However, further studies are proposed to predict the effects of this substance and to safely use these nanoparticles.
Key words: Liver enzyme, Titanium oxide nanoparticles, Zinc oxide nanoparticles, Mice
Funding: This research was funded by University of Mohaghegh Ardabili.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of University of Mohaghegh Ardabili approved the study.
How to cite this article: Arbabi S, Bayrami A, Sheidaii P. An Investigation of the Toxicity of Zinc Oxide and Titanium Oxide Nanoparticles on Some Liver Enzymes in Male Mice. J Rafsanjan Univ Med Sci 2017; 16(7): 633-44. [Farsi]
[2]- Assistant Prof., Dept. of Biology, Faculty of Basic Sciences, University of Mohagegh Ardabili, Ardabili, Iran
(Corresponding Author) Tell: (045) 33513915, Fax: (045) 33514701, Email: a_bayrami@uma.ac.ir
(Corresponding Author) Tell: (045) 33513915, Fax: (045) 33514701, Email: a_bayrami@uma.ac.ir
Type of Study: Research |
Subject:
Physiology
Received: 2017/02/12 | Accepted: 2017/09/23 | Published: 2017/10/22
Received: 2017/02/12 | Accepted: 2017/09/23 | Published: 2017/10/22
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