Volume 17, Issue 2 (5-2018)
JRUMS 2018, 17(2): 131-142 |
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Khanzadeh N, Poozesh Jadidi R, Nour Azar M. The Effect of Eight Weeks of Aerobic Exercise on Plasma Levels of Paraoxonase-1 and Lipid Hydroperoxide in Diabetic Male Rats Treated with Chlorella Algae
. JRUMS 2018; 17 (2) :131-142
URL: http://journal.rums.ac.ir/article-1-3836-en.html
URL: http://journal.rums.ac.ir/article-1-3836-en.html
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The Effect of Eight Weeks of Aerobic Exercise on Plasma Levels of Paraoxonase-1 and Lipid Hydroperoxide in Diabetic Male Rats Treated with Chlorella Algae
N. Khanzadeh[1], R. Poozesh Jadidi[2], M.A. Nour Azar[3]
Received:10/06/2017 Sent for Revision:12/07/2017 Received Revised Manuscript:28/02/2018 Accepted: 05/03/2018
Background and Objectives: Aerobic exercise and taking chlorella supplementation to control oxidative stress markers and paraoxonase-1 (PON1) levels in diabetic patients is of great importance. So, the aim of the present research was to investigate the effect of eight-week aerobic exercise on paraoxonase-1 and lipid hydroperoxide plasma levels in diabetic Wistar rats treated with chlorella algae.
Material and Methods: The present study was an experimental research. 50 male Wistar rats were randomly divided into 5 groups of 10: control, diabetic, diabetic with taking supplement (colorella), diabetic with training, and combined diabetic (training+ supplement) groups. Training and taking supplement continued for 8 weeks after diabetes induction; at the end of the 8th week, the levels of paraoxonase-1 and lipid hydroperoxide were measured. Data were analyzed using one-way ANOVA and Tukey’s post hoc test.
Results: The results showed that there were significant differences between the groups in terms of paraoxonase-1(p=0.001). Comparison between the groups of chlorella and training (p=0.001) and the combined and chlorella (p=0.001) as well as the exercise and combined (p=0.007) showed a significant difference. Also, there were significant differences between the groups in terms of lipid hydroperoxide (p=0.001). So that there was a significant difference between the training and chlorella (p=0.005) and combined groups (p=0.001) and the combined and exercise groups (p=0.029). So that in the combined group, paraoxonase -1 was further increased.
Conclusion: Eight weeks of aerobic training along with taking chlorella can remarkably reduce lipid hydroperoxide and increase paraoxonase-1 in rats with diabetes; However, their separate protocls can be also useful.
Key words: Diabetes, Aerobic exercise, Algae chlorella, Paraoxonase-1, Lipid hydroperoxide, Rat
Funding: This study was funded by Islamic Azad University, Tabriz Branch.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Islamic Azad University, Tabriz Branch approved the study.
How to cite this article: Khanzadeh N, Poozesh Jadidi R, Nour Azar MA. The Effect of Eight Weeks of Aerobic Exercise on Plasma Levels of Paraoxonase-1 and Lipid Hydroperoxide in Diabetic Male Rats Treated with Chlorella Algae. Univ Med Sci 2018; 17 (2): 131-42 [Farsi]
N. Khanzadeh[1], R. Poozesh Jadidi[2], M.A. Nour Azar[3]
Received:10/06/2017 Sent for Revision:12/07/2017 Received Revised Manuscript:28/02/2018 Accepted: 05/03/2018
Background and Objectives: Aerobic exercise and taking chlorella supplementation to control oxidative stress markers and paraoxonase-1 (PON1) levels in diabetic patients is of great importance. So, the aim of the present research was to investigate the effect of eight-week aerobic exercise on paraoxonase-1 and lipid hydroperoxide plasma levels in diabetic Wistar rats treated with chlorella algae.
Material and Methods: The present study was an experimental research. 50 male Wistar rats were randomly divided into 5 groups of 10: control, diabetic, diabetic with taking supplement (colorella), diabetic with training, and combined diabetic (training+ supplement) groups. Training and taking supplement continued for 8 weeks after diabetes induction; at the end of the 8th week, the levels of paraoxonase-1 and lipid hydroperoxide were measured. Data were analyzed using one-way ANOVA and Tukey’s post hoc test.
Results: The results showed that there were significant differences between the groups in terms of paraoxonase-1(p=0.001). Comparison between the groups of chlorella and training (p=0.001) and the combined and chlorella (p=0.001) as well as the exercise and combined (p=0.007) showed a significant difference. Also, there were significant differences between the groups in terms of lipid hydroperoxide (p=0.001). So that there was a significant difference between the training and chlorella (p=0.005) and combined groups (p=0.001) and the combined and exercise groups (p=0.029). So that in the combined group, paraoxonase -1 was further increased.
Conclusion: Eight weeks of aerobic training along with taking chlorella can remarkably reduce lipid hydroperoxide and increase paraoxonase-1 in rats with diabetes; However, their separate protocls can be also useful.
Key words: Diabetes, Aerobic exercise, Algae chlorella, Paraoxonase-1, Lipid hydroperoxide, Rat
Funding: This study was funded by Islamic Azad University, Tabriz Branch.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Islamic Azad University, Tabriz Branch approved the study.
How to cite this article: Khanzadeh N, Poozesh Jadidi R, Nour Azar MA. The Effect of Eight Weeks of Aerobic Exercise on Plasma Levels of Paraoxonase-1 and Lipid Hydroperoxide in Diabetic Male Rats Treated with Chlorella Algae. Univ Med Sci 2018; 17 (2): 131-42 [Farsi]
- - MSc in Physical Education, Dept. of Physical Education and Sports Sciences, Faculty of Humanities and Education, Islamic Azad University, Tabriz, Iran
[2]- Assistant Prof., Dept. of Physical Education and Sports Sciences, Faculty of Humanities and Education, , Islamic Azad University, Tabriz, Iran, ORCID: 0000-0001-8056-8293
(Corresponding Author) Tel: (041)33318681, Fax: (041)33317146, E-mail: n.khanzade89@gmail.com
(Corresponding Author) Tel: (041)33318681, Fax: (041)33317146, E-mail: n.khanzade89@gmail.com
[3]- Assistant Prof., Dept. of Physical Education and Sports Sciences, Faculty of Humanities and Education, Islamic Azad University, Tabriz, Iran, ORCID: 0000-0002-5441-5266
Type of Study: Research |
Subject:
تربيت بدني
Received: 2017/06/1 | Accepted: 2018/03/5 | Published: 2018/05/13
Received: 2017/06/1 | Accepted: 2018/03/5 | Published: 2018/05/13
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