Volume 17, Issue 3 (5-2018)                   JRUMS 2018, 17(3): 253-274 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Arbabian M, Amirzadegan M, Tavalaee M, Nasr-Esfahani M. Oxidative Stress and Its Effects on Male Infertility: A Review Study. JRUMS. 2018; 17 (3) :253-274
URL: http://journal.rums.ac.ir/article-1-4002-en.html
Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
Abstract:   (4611 Views)
Background and Objectives: Reactive oxygen species (ROS) are essential for sperm physiological functions including capacitation, acrosome reaction, fertilization, and etc. Sperm cell in comparison with other cells is highly prone to oxidative attack due to high level of membrane unsaturated fatty acids and low volume of cytoplasmic space. Therefore, the aim of this review article was to understand the causes of oxidative stress production, the mechanisms involved in oxidative stress, its effects and therapeutic strategies for infertile men.
Materials and Methods: For this review, all relevant information were collected via databases such as PubMed and Google Scholar, and totally, information were extracted from 60 articles.
Results: Several studies showed that level of pathological ROS was significantly higher in infertile men in comparison to fertile men, and under these conditions, high level of sperm apoptotic, loss of mitochondrial membrane potential, caspase activation, sperm phosphatidylserine exposure, oxidative DNA damage, and low quality of sperm parameters were observed. Oxidative damages can affect sperm DNA integrity and are associated to miscarriage and developmental abnormalities in the offspring.
Conclusion: Oxidative stress is caused by several variable factors, and the use of an effective antioxidant can decrease the oxidative stress level and improve fertility potential in couples with male infertility factor. 
Key words: Male infertility, Oxidative stress, DNA damage, Sperm parameters, Antioxidant.   
Funding: This study was supported by the Royan Institute.
Conflict of interest: None of the authors have any conflicts of interest to disclose and all authors support submission of this manuscript to this journal.
How to cite this article: Arbabian M, Amirzadegan M, Tavalaee M, Nasr-Esfahani M.H. Oxidative Stress and Its Effects on Male Infertility: A Review Study. Univ Med Sci 2018; 17 (3): 253-74. [Farsi]
Full-Text [PDF 343 kb]   (4688 Downloads) |   |   Full-Text (HTML)  (10887 Views)  
Type of Study: Review Article | Subject: Urology
Received: 2017/10/12 | Accepted: 2018/05/12 | Published: 2018/06/3

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Journal of Rafsanjan University of Medical Sciences

Designed & Developed by : Yektaweb