Volume 17, Issue 11 (1-2019)
JRUMS 2019, 17(11): 989-1002 |
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Taari B, Goodarzi N. The Protective Effect of Curcumin Against Methandienone Induced Hepatotoxicity in Male Mice: An Experimental Study. JRUMS 2019; 17 (11) :989-1002
URL: http://journal.rums.ac.ir/article-1-4356-en.html
URL: http://journal.rums.ac.ir/article-1-4356-en.html
Razi University
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The Protective Effect of Curcumin Against Methandienone Induced Hepatotoxicity in Male Mice: An Experimental Study
B. Taari[1], N. Goodarzi[2]
Received: 10/07/2018 Sent for Revision: 01/10/2018 Received Revised Manuscript: 05/11/2018 Accepted: 12/12/2018
Background and Objectives: Due to the approved antioxidant effects of curcumin, this study was conducted to investigate the hepatoprotective effects of curcumin against methandienone (dianabol) induced hepatotoxicity in male mice.
Materials and Methods: In this descriptive study, 35 adult male mice (weight=35±2 g) were randomly assigned into five groups. The first group received 0.2 ml of normal saline and second group received dianabol at 20 mg/kg/day orally. The treatment groups treated with 20 mg/kg/day of dianabol plus 50, 100 and 200 mg/kg/day of curcumin, during 8 weeks by gavage. At the end of the experiment, the level of alkaline phosphatase, alanine aminotransferase and aspartate amiotrasferase enzymes were measured and the quantitative changes of liver tissue were examined using stereological procedures. The data were analyzed using one-way ANOVA and Tukey’s post-hoc test.
Results: The volume of the liver, hepatocytes, sinusoids as well as alanine aminotrasferase and alkaline phosphatase levels increased significantly in dianabol treated group as compared with the control group (p<0.05). Curcumin at 100 and 200 mg/kg doses significantly decreased the volume of the liver, hepatocytes, and sinusoides as well as the alanine aminotrasferase and alkaline phosphatase levels when compared to the dianabol treated group (p<0.05).
Conclusion: It seems that curcumin due to its anti-oxidant and anti-inflammatory properties can inhibit hepatic structural and functional alterations following dianabol administration.
Key words: Methandienone, Hepatotoxicity, Curcumin, Mice, Protective effect
Funding: This research was funded by Razi University, Kermanshah, Iran
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Razi University approved the study ( Ethic Nubmer: 396-2-014).
How to cite this article: Taari B, Goodarzi N. The Protective Effect of Curcumin Against Methandienone Induced Hepatotoxicity in Male Mice: An Experimental Study. J Rafsanjan Univ Med Sci 2019; 17 (11): 989-1002. [Farsi]
[1]- D.V.M Graduate, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran, ORCID: 0000-0003-4742-1067
(Corresponding Author) Tel: (083) 38322599, Fax: (083) 38320041, E-mail: n.goodarzi@razi.ac.ir
B. Taari[1], N. Goodarzi[2]
Received: 10/07/2018 Sent for Revision: 01/10/2018 Received Revised Manuscript: 05/11/2018 Accepted: 12/12/2018
Background and Objectives: Due to the approved antioxidant effects of curcumin, this study was conducted to investigate the hepatoprotective effects of curcumin against methandienone (dianabol) induced hepatotoxicity in male mice.
Materials and Methods: In this descriptive study, 35 adult male mice (weight=35±2 g) were randomly assigned into five groups. The first group received 0.2 ml of normal saline and second group received dianabol at 20 mg/kg/day orally. The treatment groups treated with 20 mg/kg/day of dianabol plus 50, 100 and 200 mg/kg/day of curcumin, during 8 weeks by gavage. At the end of the experiment, the level of alkaline phosphatase, alanine aminotransferase and aspartate amiotrasferase enzymes were measured and the quantitative changes of liver tissue were examined using stereological procedures. The data were analyzed using one-way ANOVA and Tukey’s post-hoc test.
Results: The volume of the liver, hepatocytes, sinusoids as well as alanine aminotrasferase and alkaline phosphatase levels increased significantly in dianabol treated group as compared with the control group (p<0.05). Curcumin at 100 and 200 mg/kg doses significantly decreased the volume of the liver, hepatocytes, and sinusoides as well as the alanine aminotrasferase and alkaline phosphatase levels when compared to the dianabol treated group (p<0.05).
Conclusion: It seems that curcumin due to its anti-oxidant and anti-inflammatory properties can inhibit hepatic structural and functional alterations following dianabol administration.
Key words: Methandienone, Hepatotoxicity, Curcumin, Mice, Protective effect
Funding: This research was funded by Razi University, Kermanshah, Iran
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Razi University approved the study ( Ethic Nubmer: 396-2-014).
How to cite this article: Taari B, Goodarzi N. The Protective Effect of Curcumin Against Methandienone Induced Hepatotoxicity in Male Mice: An Experimental Study. J Rafsanjan Univ Med Sci 2019; 17 (11): 989-1002. [Farsi]
- - Assistant Prof., Dept. of Basic and Pathobiological Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
(Corresponding Author) Tel: (083) 38322599, Fax: (083) 38320041, E-mail: n.goodarzi@razi.ac.ir
Type of Study: Applicable |
Subject:
Pharmacology
Received: 2018/07/3 | Accepted: 2018/12/12 | Published: 2019/01/15
Received: 2018/07/3 | Accepted: 2018/12/12 | Published: 2019/01/15
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