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JRUMS 2020, 19(1): 39-52 |
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Taherzadeh S, Mogharnasi M, Rasoulian B, Kaeidi A, Khosravi A. The Effect of 6 Weeks Aerobic Training and Aqueous Extract of Caraway Seed (Carum Carvi) on the Expression of CTRP12 Gene, Body Weight Changes and Subcutaneous Adipose Tissue in Obese Male Rats: An Experimental Study. JRUMS 2020; 19 (1) :39-52
URL: http://journal.rums.ac.ir/article-1-5012-en.html
URL: http://journal.rums.ac.ir/article-1-5012-en.html
Faculty of Sport Sciences, University of Birjand, Birjand, Iran
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The Effect of 6 Weeks Aerobic Training and Aqueous Extract of Caraway Seed (Carum Carvi) on the Expression of CTRP12 Gene, Body Weight Changes and Subcutaneous Adipose Tissue in Obese Male Rats: An Experimental Study
S[j1] . Taherzadeh[1], M. Mogharnasi[2], B. Rasoulian[3], A. Kaeidi[4], A. Khosravi[5]
Received: 26/10/2019 Sent for Revision: 14/12/2019 Received Revised Manuscript: 23/12/2019 Accepted: 28/12/2019
Background and Objectives: Caraway (Carum carvi) is one of the medicinal plants which is traditionally used for weight loss. The purpose of the present study was to determine the effect of 6 weeks aerobic training and aqueous extract of caraway seed (carum carvi) on expression of CTRP12 gene, body weight changes and subcutaneous adipose tissue in obese male rats.
Materials and Methods: In this experimental study, 24 fat male rats were provided a high-fat diet for 12 weeks to induce obesity, following which they were divided randomly into four groups: 1. high-fat control diet, 2. high-fat diet+ exercise, 3. high-fat diet+caraway, 4. high-fat diet+exercise+caraway. The training groups performed aerobic exercise 5 days in week for 6 weeks (approximately 50-70% VO2max). Relative expression of CTRP12 mRNA was measured using real-time polymerase chain reaction (real-time PCR), body weight changes and subcutaneous adipose tissue. Data were analyzed using one-way ANOVA and Tukey’s post hoc test.
Results: Relative expression of CTRP12 mRNA significantly increased after 6 weeks of aerobic training and consumption of carum carvi extract in group 4 compared to groups 1 and 3, in group 1 compared to group 2, and animal weight and subcutaneous fat weight in groups 4, 3 and 2 significantly decreased compared to group 1.
Conclusions: Considering the results of the present study, it is recommended to use moderate aerobic exercise and carum carvi to reduce the risk of obesity and weight.
Key words: Aerobic training, Caraway, CTRP12, Subcutaneous fat, High-fat diet, Rat, Obesity
Funding: This study was funded by Sedigheh Taherzadeh.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of the Sport Sciences Research Institute of Iran approved the study (IR.SSRI.REC.1397.395).
How to cite this article: Taherzadeh S, Mogharnasi M, Rasoulian B, Kaeidi A, Khosravi A. The Effect of 6 Weeks Aerobic Training and Aqueous Extract of Caraway Seed (Carum Carvi) on the Expression of CTRP12 Gene, Body Weight Changes and Subcutaneous Adipose Tissue in Obese Male Rats: An Experimental Study. J Rafsanjan Univ Med Sci 2020; 19 (1): 39-52. [Farsi]
[1]- PhD Student of Sport Biochemistry and Metabolism, Faculty of Sport Sciences, University of Birjand, Birjand, Iran, ORCID: 0000-0003-2283-9942
S[j1] . Taherzadeh[1], M. Mogharnasi[2], B. Rasoulian[3], A. Kaeidi[4], A. Khosravi[5]
Received: 26/10/2019 Sent for Revision: 14/12/2019 Received Revised Manuscript: 23/12/2019 Accepted: 28/12/2019
Background and Objectives: Caraway (Carum carvi) is one of the medicinal plants which is traditionally used for weight loss. The purpose of the present study was to determine the effect of 6 weeks aerobic training and aqueous extract of caraway seed (carum carvi) on expression of CTRP12 gene, body weight changes and subcutaneous adipose tissue in obese male rats.
Materials and Methods: In this experimental study, 24 fat male rats were provided a high-fat diet for 12 weeks to induce obesity, following which they were divided randomly into four groups: 1. high-fat control diet, 2. high-fat diet+ exercise, 3. high-fat diet+caraway, 4. high-fat diet+exercise+caraway. The training groups performed aerobic exercise 5 days in week for 6 weeks (approximately 50-70% VO2max). Relative expression of CTRP12 mRNA was measured using real-time polymerase chain reaction (real-time PCR), body weight changes and subcutaneous adipose tissue. Data were analyzed using one-way ANOVA and Tukey’s post hoc test.
Results: Relative expression of CTRP12 mRNA significantly increased after 6 weeks of aerobic training and consumption of carum carvi extract in group 4 compared to groups 1 and 3, in group 1 compared to group 2, and animal weight and subcutaneous fat weight in groups 4, 3 and 2 significantly decreased compared to group 1.
Conclusions: Considering the results of the present study, it is recommended to use moderate aerobic exercise and carum carvi to reduce the risk of obesity and weight.
Key words: Aerobic training, Caraway, CTRP12, Subcutaneous fat, High-fat diet, Rat, Obesity
Funding: This study was funded by Sedigheh Taherzadeh.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of the Sport Sciences Research Institute of Iran approved the study (IR.SSRI.REC.1397.395).
How to cite this article: Taherzadeh S, Mogharnasi M, Rasoulian B, Kaeidi A, Khosravi A. The Effect of 6 Weeks Aerobic Training and Aqueous Extract of Caraway Seed (Carum Carvi) on the Expression of CTRP12 Gene, Body Weight Changes and Subcutaneous Adipose Tissue in Obese Male Rats: An Experimental Study. J Rafsanjan Univ Med Sci 2020; 19 (1): 39-52. [Farsi]
[2]- Associate Prof. of Exercise Physiology, Faculty of Sport Sciences, University of Birjand, Birjand, Iran, ORCID: 0000-0002-9351-5948
(Corresponding Author) Tel: (056) 32202240, Fax: (056) 32202240, Email: mogharnasi@birjand.ac.ir
(Corresponding Author) Tel: (056) 32202240, Fax: (056) 32202240, Email: mogharnasi@birjand.ac.ir
[3]- Prof. of Medical Physiology, Dept. of Physiology, Lorestan University of Medical Sciences, Lorestan, Iran, ORCID: 0000-0003-0730-4376
[4]- Assistant Prof. of Medical Physiology, Dept. of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, ORCID: 0000-0002-3292-2603.
[5]- Assistant Prof. of Exercise Physiology, Dept. of Physical Education, Ayatollah Boroujerdi University, Boroujerd, Iran, ORCID: 0000-0002-4728-8991
Type of Study: Research |
Subject:
تربيت بدني
Received: 2019/10/21 | Accepted: 2019/12/28 | Published: 2020/04/22
Received: 2019/10/21 | Accepted: 2019/12/28 | Published: 2020/04/22
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