Background and Objectives: Non alcoholic fatty liver disease is a common disease with an increased risk of atherosclerotic changes of the vascular structures, which could lead to vascular disease. This study has been carried out to evaluate the significant relationship among non alcoholic fatty liver disease and hemodynamic criterion of the intracranial vessels by transcranial doppler ultrasound as a non invasive method.
Matrials and Methods: In this cross sectional study, involving 47 subjects ages 23 to 68, who had been evaluated for hemodynamic criterion of the intracranial vessels by transcranial doppler ultrasound were studied. Subjects were divided  based on the ultrasound criterion for fatty liver disease as follows: mild (10 patients), moderate (10 patients) and severe (11 patients). ANOVA and K2 were used to analyze the data.
Results: The results indicated that the hemodynamic criterion of intracranial cerebral vessels, pulsatility index (PI) and resistance index (RI) in anterior, middle and posterior cerebral arteries and internal carotid arteries in severe non alcoholic fatty liver group were significantly higher as compared to control group (p<0.05).
There was a significant increased in these hemodynamic criterion values in middle cerebral arteries in non alcoholic moderate fatty liver group as compared to the control group (p<0.05).
Conclusion: Increase in the values of pulsatility index (PI) and resistance index (RI) of the intracranial cerebral vessels in moderate and severe non alcoholic fatty liver groups could be related to atherosclerotic changes of the intracranial vessels owing to malfunction of the cellular endothelium secondary to non alcoholic fatty liver disease as part of the metabolic syndrom, emphysis the significance control of the atherosclerotic risk factors and early prevention and treatment of intracranial vessels disease to reduce complications of the non alcoholic fatty liver disease.
Key words: non alcoholic fatty liver disease (NAFLD) - trans cranial doppler ultrasound - hemodynamic criterion of intracranial cerebral arteries
 
Funding:This research was funded by Neuroscience Research Center of Kerman University College of medicine.
Conflict of interest:None declared.
Etical approval: The Ethics committee of Kerman University College of medicine approved the study by number: EC/KNRC/88-35
How to cite this article: Fahimi F, Shafiee K, Ahmadi J, Mehrabian M, Pezeshki E, A. Dehgani Relationship Between Non Alcoholic Fatty Liver Disease with Hemodynamic Indexes of Intracranial Cerebral Vessels in Transcranial Doppler Ultrasound. J Rafsanjan Univ Med Sci 2013; 11(6): 567-74. [Farsi]

Keywords: non alcoholic fatty liver disease (NAFLD) - trans cranial doppler ultrasound - hemodynamic criterion of intracranial cerebral arteries

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