Volume 8, Issue 3 (12-2009)
JRUMS 2009, 8(3): 239-244 |
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The Comparison of the Level of Serum Concentration of Gro-Α Chemokine in Diabetic Type-2 Patients and Healthy People: A Short Communication. JRUMS 2009; 8 (3) :239-244
URL: http://journal.rums.ac.ir/article-1-5357-en.html
URL: http://journal.rums.ac.ir/article-1-5357-en.html
Abstract: (1469 Views)
Background and Objectives: Type-2 diabetes mellitus is the most common type of diabetes, but the main cause of which is yet to be identified. One of the symptoms of diabetes is delay in healing of the wounds. Chemokines play key roles in both the regulation of immune system functions and regeneration of the damaged tissues. Growth-regulatory oncogen (Gro) is an angiogenesis chemokine. Therefore, we dicided to compare the serum level of Gro-α chemokine in diabetic patients and healthy people.
Material and Methods: In this descriptive study respondents were 45 diabetic and 45 healthy people referred to Ali Ibn Abitaleb hospital in Rafsanjan. The level of Gro-α was detected by ELISA. Data were analysed using SPSS version 12. T-test was used to compare continuous data.
Results: Although there were differences between diabetic and healthy people based on the serum level of Gro-a chemokine, this difference was not significant.
Conclusion: Based on our results, it can be concluded that diabetic patients are unable to produce enough Gro-a and this can be the reason for the delay in healing of the wounds. Furthermore, to assess the role of this chemokine more number of samples are needed for examination.
Key word: Chemokine, Gro-a, Angiogenesis, Diabetes
Funding: This research was funded by Rafsanjan University of Medical Sciences.
Conflict of interest: None declared.
Ethical approval: The Ethical Committee of Rafsanjan University of Medical Sciences approved the study.
Material and Methods: In this descriptive study respondents were 45 diabetic and 45 healthy people referred to Ali Ibn Abitaleb hospital in Rafsanjan. The level of Gro-α was detected by ELISA. Data were analysed using SPSS version 12. T-test was used to compare continuous data.
Results: Although there were differences between diabetic and healthy people based on the serum level of Gro-a chemokine, this difference was not significant.
Conclusion: Based on our results, it can be concluded that diabetic patients are unable to produce enough Gro-a and this can be the reason for the delay in healing of the wounds. Furthermore, to assess the role of this chemokine more number of samples are needed for examination.
Key word: Chemokine, Gro-a, Angiogenesis, Diabetes
Funding: This research was funded by Rafsanjan University of Medical Sciences.
Conflict of interest: None declared.
Ethical approval: The Ethical Committee of Rafsanjan University of Medical Sciences approved the study.
Type of Study: Short Report |
Subject:
Microbiology
Received: 2020/05/16 | Accepted: 2020/05/16 | Published: 2020/05/16
Received: 2020/05/16 | Accepted: 2020/05/16 | Published: 2020/05/16
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