Volume 2, Issue 3 And 3-4 (9-2003)
JRUMS 2003, 2(3 And 3-4): 269-274 |
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Frozen Section Efficiency in Determination of Thyroid Nodules. JRUMS 2003; 2 (3 and 3-4) :269-274
URL: http://journal.rums.ac.ir/article-1-5432-en.html
URL: http://journal.rums.ac.ir/article-1-5432-en.html
Abstract: (1407 Views)
Background: This retrospective study was undertaken to assess frozen section accuracy in patients undergoing Thyroidectomy.
Background: During thyroid operations, excised tissue studied via frozen section by a pathologist can differentiate benign lesions from a malignant ones and help guide the surgeon during the procedure. In recent decades the role of frozen section in defining the nature of thyroid nodules has been declining, being replaced by fine needle aspiration (FNA) despite the fact that in many cases the diagnosis may be missed. In many instances frozen section may be more reliable especially when experienced pathologists are not at hand or when preoperative FNAs are inconclusive or suspicious for malignancy.
Materials and Methods: This retrospective study included 84 patients undergoing thyroidectomy In 5 years . There were 17 males and 67 females. Mean age was 36 years (ranging from 15 to 70 years). All patients had thyroid nodules and underwent thyroeidectomy at our medical center. Frozen sections from tissue samples excised during operation were evaluated for all patients.
Results: According to histopathological exam, there were 12 (14.3%) thyroid cancers and 72(85.7%) benign thyroid diseases. Incidence of malignancy was 29.4 % in men and 10.4% in women. When compared with final pathology reports, frozen section reports were correct in 95.3%. There were two false negative and two false positive reports (4.7%). Sensitivity and specificity of this method were 83% and 98% respectively. Positive predictive value and negative predictive value were 83% and 98% respectively.
Conclusions: Frozen section is a reliable and valuable method for surgeons involved in thyroid surgery and may be preferred over FNA when experienced pathologists are not at hand or when preoperative FNAs are inconclusive or suspicious for malignancy.
Keywords : Frozen Section, Thyroid Nodules, Thyroidectomy, Thyroid Cancer.
Background: During thyroid operations, excised tissue studied via frozen section by a pathologist can differentiate benign lesions from a malignant ones and help guide the surgeon during the procedure. In recent decades the role of frozen section in defining the nature of thyroid nodules has been declining, being replaced by fine needle aspiration (FNA) despite the fact that in many cases the diagnosis may be missed. In many instances frozen section may be more reliable especially when experienced pathologists are not at hand or when preoperative FNAs are inconclusive or suspicious for malignancy.
Materials and Methods: This retrospective study included 84 patients undergoing thyroidectomy In 5 years . There were 17 males and 67 females. Mean age was 36 years (ranging from 15 to 70 years). All patients had thyroid nodules and underwent thyroeidectomy at our medical center. Frozen sections from tissue samples excised during operation were evaluated for all patients.
Results: According to histopathological exam, there were 12 (14.3%) thyroid cancers and 72(85.7%) benign thyroid diseases. Incidence of malignancy was 29.4 % in men and 10.4% in women. When compared with final pathology reports, frozen section reports were correct in 95.3%. There were two false negative and two false positive reports (4.7%). Sensitivity and specificity of this method were 83% and 98% respectively. Positive predictive value and negative predictive value were 83% and 98% respectively.
Conclusions: Frozen section is a reliable and valuable method for surgeons involved in thyroid surgery and may be preferred over FNA when experienced pathologists are not at hand or when preoperative FNAs are inconclusive or suspicious for malignancy.
Keywords : Frozen Section, Thyroid Nodules, Thyroidectomy, Thyroid Cancer.
Type of Study: Research |
Subject:
Surgery
Received: 2020/06/10 | Accepted: 2020/06/10 | Published: 2020/06/10
Received: 2020/06/10 | Accepted: 2020/06/10 | Published: 2020/06/10
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