Volume 8, Issue 1 (6-2009)                   JRUMS 2009, 8(1): 3-10 | Back to browse issues page

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Ayatollahi Mousavi S, Yaghmai B, Mehrabian M. The Study of the Effects of Aqueous and Methanol Extracts of Garlic Against Trichophyton Mentagrophytes, Microsporum canis & Microsporum Gypseum. JRUMS. 2009; 8 (1) :3-10
URL: http://journal.rums.ac.ir/article-1-552-en.html
Abstract:   (14393 Views)

  The Study of the Effects of Aqueous and Methanol Extracts of Garlic Against Trichophyton Mentagrophytes, Microsporum canis & Microsporum Gypseum


  S.A. Ayatollahi Mousavi [1] , B. Yaghmai [2] , M. Mehrabian [3]


  Received: 05/05/07 Sent for Revision: 09/10/07 Received Revised Manuscript: 27/05/08 Accepted: 15/11/08


  Background and Objectives: Although, more than three hundred thousands types of herbs have been recognized so far, just ten thousand ones have been tested for their pharmacological specificity. Garlic which is not used daily has antiseptic, antibacterial, antihelminths and blood pressure reducing specificities. The objectives of this study are to: 1) study the antifungal activity of the aqueous and methanol extracts of garlic on Trichophyton mentagrophytes, Microsporum gypseum and Microsporum canis. 2) know the minimum amount of inhibitory concentration (MIC) of the garlic extracts on these dermatophytes. 3) compare the effects of the different dilutions of garlic extracts with ketoconazole.

  Materials and Methods: In this laboratory study, the fresh bulb of garlic was cleaned, skinned, dried and powdered. Garlic powder was solved in 80% methanol and distilled water. This yellow solution remained in lab for four days. After steaming, filtering and concentrating, the concentrated solution was kept inside the pipette in oven for 48h in 50ºC in order to make the dry extract. Methanol and aqueous dilutions (0.625 mg/ml, 1.25 mg/ml 2.5 mg/ml, 5 mg/ml, 10mg/ml and 20 mg/ml), from 200mg powder of the concentrated extracts of garlic were prepared separately. Three strains of dermatophytes were cultured on the media which contained different dilutions.

  Results: The MIC of the aqueous and methanol extracts of garlic on T. mentagrophytes and M. canis was the same however, the effect of methanol extract on M. gypseum was more than effect of the aqueous extract. In total, extract dilations of 10mg/ml and 20 mg/ml had the highest effects on the growth of these dermatophytes.

  Conclusion: On the basis of the results of this study, it is clear that garlic plant in either aquatic or methanolic extract could be effective against Geophilic, Zoophilic & Anthropophilic fungi


  Key words: Allium sativum , ِِ Dermatophyte, Trichophyton mentagrophytes, Microsporum canis, Microsporum gypseum


  Funding: This research was funded by Kerman University of Medical Sciences.

  Conflict of Interest: None declared.

  Ethical approval: TheEthics Committee of Kerman University of Medical Sciences, approved the study.


  [1] - Associated Prof., Dept. of Clinical Mycology and Parasitology, School of Medical, University of Medical Sciences, Kerman, Iran

  (Corresponding Author) Tel: (0341) 3221676, Fax: (0341) 3221676, E-mail: aminayatollahi@kmu.ac.ir

  [2] - Prof., Dept. of Biochemistry, School of Medical, Shahid Beheshti University of Medical Sciences, Tehran, Iran

  [3] - Medical Student, School of Medical, University of Medical Sciences, Rafsanjan , Iran

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Type of Study: Research | Subject: Statistics& Epidemiology
Received: 2009/06/3 | Published: 2009/06/15

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