Volume 20, Issue 2 (5-2021)
JRUMS 2021, 20(2): 201-226 |
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Rashidi S, Asadi A, Abdolmaleki A. Cancer Stem Cells: A Narrative Review. JRUMS 2021; 20 (2) :201-226
URL: http://journal.rums.ac.ir/article-1-5780-en.html
URL: http://journal.rums.ac.ir/article-1-5780-en.html
Mohaghegh Ardabili
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Cancer Stem Cells: A Narrative Review
S. Rashidi[1], A. Asadi [2], A. Abdolmaleki[3],[4]
Received:11/01/21 Sent for Revision: 31/02/21 Received Revised Manuscript:17/03/21 Accepted:28/03/21
Cancer Stem Cells (CSCs) or tumor-initiating cells are a subpopulation of cells within the heterogenous tumor with the potential for self-renewal and differentiation into various cell lines. They also have a high tumorigenic potential in all tissues and organs of the body compared to other stem cells. CSCs reside in special microenvironments that are referred to as the niche. CSCs niches are comprised of different types of cells that cause CSCs to be survived and their features to be improved. In this review article, CSCs features, their separation and identification methods and bilateral relationship between CSCs and niches have been examined. Also, major signaling pathways such as Wnt/βcatenin, Notch, Hedgehog and Hippo that are frequently altered in CSCs and provide a supportive role for CSCs, and the therapeutic targets of these pathways, that are effective in eradicating CSCs and cancer treatment, have been studied.
Key words: Cancer stem cells, Signaling-pathways, Tumor.
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical approval: None declared.
How to cite this article: Rashidi S, Asadi A, Abdolmaleki A. Cancer Stem Cells: A Narrative Review. J Rafsanjan Univ Med Sci 2021; 20 (2): 201-26. [Farsi]
[1]- MSc, Dept. of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran, ORCID: 0000-0003-3315-2947
S. Rashidi[1], A. Asadi [2], A. Abdolmaleki[3],[4]
Received:11/01/21 Sent for Revision: 31/02/21 Received Revised Manuscript:17/03/21 Accepted:28/03/21
Cancer Stem Cells (CSCs) or tumor-initiating cells are a subpopulation of cells within the heterogenous tumor with the potential for self-renewal and differentiation into various cell lines. They also have a high tumorigenic potential in all tissues and organs of the body compared to other stem cells. CSCs reside in special microenvironments that are referred to as the niche. CSCs niches are comprised of different types of cells that cause CSCs to be survived and their features to be improved. In this review article, CSCs features, their separation and identification methods and bilateral relationship between CSCs and niches have been examined. Also, major signaling pathways such as Wnt/βcatenin, Notch, Hedgehog and Hippo that are frequently altered in CSCs and provide a supportive role for CSCs, and the therapeutic targets of these pathways, that are effective in eradicating CSCs and cancer treatment, have been studied.
Key words: Cancer stem cells, Signaling-pathways, Tumor.
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical approval: None declared.
How to cite this article: Rashidi S, Asadi A, Abdolmaleki A. Cancer Stem Cells: A Narrative Review. J Rafsanjan Univ Med Sci 2021; 20 (2): 201-26. [Farsi]
[2]- Associate Prof., Dept. of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran, ORCID: 0000-0003-3314-2948 (Corresponding Author) Tel: (045) 31505187, Fax: (045) 31505187, E-mail: asad.asady@gmail.com
[3]- Assistant Prof., Dept.of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran, ORCID: 0000-0002-7454-8728
Type of Study: Review Article |
Subject:
زيست شناسي
Received: 2021/01/9 | Accepted: 2021/03/28 | Published: 2021/05/20
Received: 2021/01/9 | Accepted: 2021/03/28 | Published: 2021/05/20
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