Journal of Rafsanjan University of Medical Sciences

 Serum HDL2-C Evaluation in Patients with Coronary

 Heart Disease

  S. Hasannia^{1 *} M.Sc, F. Mir Blook² MD, A.S. Lotfi³ Ph.D, A. Mohsenifar³ MS.c, M. Mahmoodi⁴ Ph.D

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  1- Academic Member, Dept. of Biology, Guilan University of Medical Sciences. Rasht, Iran.

  2- Assistant Professor of Cardiology Heart Center of Dr. Heshmat Hospital, Guilan University of Medical Sciences. Rasht, Iran.

  3- Assistant Professor, Dept. of Clinical Biochemistry, Faculty of Medical Sciences. Tarbiat Modarres University, Tehran, Iran.

  4- Assistant Professor Dept. of Clinical Biochemistry, Rafsanjan Faculty of Medicine. Rafsanjan, Iran.

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  Background : The evaluation of blood lipids and lipoproteins especially the ratio of them is one of the initial action in assessment of the vascular performance. In recent years, the evaluation of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subgroups have become important to determine the vascular efficiency. Therefore regional research to evaluate these subgroups is essential. HDLs reduce the risk of cardiovascular diseases thus, they are the main anti-risk factor for the coronary heart disease (CHD) especially atherosclerosis and myocardial infarction. HDLs grossly consist of two subgroups, HDL2-C and HDL3-C. Many studies have shown that reporting HDL2-C subgroup is more useful than total HDL-C. The aim of this study was to determine the concentration of HDL-C, HDL2-C, and HDL3-C and relating them to coronary heart disease, in a number of patients hospitalised in Dr. Heshmat^,s Hospital of Rasht.

  Materials and Methods: The relationship of plasma level of lipid status such as total cholesterol (TC), total HDL, HDL subfractions (HDL2, HDL3), TAG, LDL, VLDL, to the incidence of coronary heart disease (CHD) was measured by enzymatic and precipitation methods, in 191 sera from 125 men and 66 women (15-73 years old), who were referred for coronary angiography, in angiography department of specialized Dr. Heshmat hospital in Rasht. From the 191 patients, 58 (37 men & 21 women 15-70 years old) were found to have no CHD and 133 (88 men & 45 women 31-73 years old) had CHD assessed by coronary angiography.

  Results : Statistical analysis (student's t-test) Showed a significant correlations between the concentration of TC, TAG, LDL-C, VLDL-C, HDL-C, HDL2-C, LDL-C/HDL-C, HDL2-C/HDL3-C, TC/HDL-C and CHD (p<0.05). There was no significant difference between HDL3-C, TC/LDL, and HDL2-C/HDL.

  Conclusion : The findings of this study suggest that factors that influence CHD risk do so in part through modifying HDL2-C levels. Moreover in many cases the ratio of HDL2/HDL3,TC/HDL and LDL/HDL can be used instead of measurment of these factors individually.

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  Key words: CHD, HDL, Angiography, Lipids

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  * Corresponding Author: Tel: (021)8011001

  J0urnal of Rafsanjan University of Medical Sciences and Health Services,2003,2(2 ( , 74-81.

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