Volume 21, Issue 9 (12-2022)
JRUMS 2022, 21(9): 971-986 |
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Doroudchi A, Zarenezhad M, Hosseininezhad H, Ramezannezhad P, Gharedaghi J, Zareijelyani N et al . MicroRNAs, Y Chromosome, and Computational Biology in Forensic Medicine: A Review Study. JRUMS 2022; 21 (9) :971-986
URL: http://journal.rums.ac.ir/article-1-6670-en.html
URL: http://journal.rums.ac.ir/article-1-6670-en.html
Alireza Doroudchi 
, Mohammad Zarenezhad , Homayoun Hosseininezhad , Pantea Ramezannezhad , Jaber Gharedaghi , Najmeh Zareijelyani , Abdolrasool Malekpour
, Mohammad Zarenezhad , Homayoun Hosseininezhad , Pantea Ramezannezhad , Jaber Gharedaghi , Najmeh Zareijelyani , Abdolrasool Malekpour
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MicroRNAs, Y Chromosome, and Computational Biology in Forensic Medicine: A Review Study
Alireza Doroudchi[1], Mohammad Zarenezhad[2], Homayoun Hosseininezhad[3], Pantea Ramezannezhad [4], Jaber Gharedaghi [5], Najmeh Zareijelyani [6], Abdolrasool Malekpour [7]
Received: 22/08/22 Sent for Revision: 26/10/22 Received Revised Manuscript: 27/11/22 Accepted: 28/11/22
Background and Objectives: The analysis of molecular profiles in molecular genetic techniques of forensic medicine has played an important role in developing diagnostic methods. The purpose of this study is to review the latest advances in forensic medicine in the light of modern molecular sciences and their potential and actual applications in forensic medicine.
Materials and Methods: In this review study, the related articles were extracted and used from databases such as Google Scholar, PubMed, Magiran, and Scopus using keywords “microRNAs”, “Y chromosome”, and “computational biology”, in a time interval from 2010-2022.
Results: Due to their short size, miRNAs are promising biomarkers in forensic medicine and are especially valuable for degraded samples or complex mixed samples. miRNA analysis allows the simultaneous identification of hundreds of miRNAs with few copies in a single experiment and can be done using indexing techniques such as microarray techniques. Using these indexes in the crime scene investigations can help to identify and find unknown male perpetrators and their paternal origin. Bioinformatics also provides valuable potentials for forensic medicine by merging mathematics and statistics and molecular genetic techniques.
Conclusion: The development and standardization of efficient and desirable tools for data processing is being done, and more accurate and faster methods have been developed to improve the original methods.
Key words: Forensic medicine, miRNA, Y-STR, Bioinformatics
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical approval: The present study was conducted after approvals by research committee of Fars Province General Administration of Forensic Medicine.
How to cite this article: Doroudchi Alireza, Zarenezhad Mohammad, Hosseininezhad Homayoun, Ramezannezhad Pantea, Gharedaghi Jaber, Zareijelyani Najmeh, Malekpour Abdolrasool. MicroRNAs, Y Chromosome, and Computational Biology in Forensic Medicine: A Review Study. J Rafsanjan Univ Med Sci 2022; 21 (9): 971-86. [Farsi]
Alireza Doroudchi[1], Mohammad Zarenezhad[2], Homayoun Hosseininezhad[3], Pantea Ramezannezhad [4], Jaber Gharedaghi [5], Najmeh Zareijelyani [6], Abdolrasool Malekpour [7]
Received: 22/08/22 Sent for Revision: 26/10/22 Received Revised Manuscript: 27/11/22 Accepted: 28/11/22
Background and Objectives: The analysis of molecular profiles in molecular genetic techniques of forensic medicine has played an important role in developing diagnostic methods. The purpose of this study is to review the latest advances in forensic medicine in the light of modern molecular sciences and their potential and actual applications in forensic medicine.
Materials and Methods: In this review study, the related articles were extracted and used from databases such as Google Scholar, PubMed, Magiran, and Scopus using keywords “microRNAs”, “Y chromosome”, and “computational biology”, in a time interval from 2010-2022.
Results: Due to their short size, miRNAs are promising biomarkers in forensic medicine and are especially valuable for degraded samples or complex mixed samples. miRNA analysis allows the simultaneous identification of hundreds of miRNAs with few copies in a single experiment and can be done using indexing techniques such as microarray techniques. Using these indexes in the crime scene investigations can help to identify and find unknown male perpetrators and their paternal origin. Bioinformatics also provides valuable potentials for forensic medicine by merging mathematics and statistics and molecular genetic techniques.
Conclusion: The development and standardization of efficient and desirable tools for data processing is being done, and more accurate and faster methods have been developed to improve the original methods.
Key words: Forensic medicine, miRNA, Y-STR, Bioinformatics
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical approval: The present study was conducted after approvals by research committee of Fars Province General Administration of Forensic Medicine.
How to cite this article: Doroudchi Alireza, Zarenezhad Mohammad, Hosseininezhad Homayoun, Ramezannezhad Pantea, Gharedaghi Jaber, Zareijelyani Najmeh, Malekpour Abdolrasool. MicroRNAs, Y Chromosome, and Computational Biology in Forensic Medicine: A Review Study. J Rafsanjan Univ Med Sci 2022; 21 (9): 971-86. [Farsi]
[1]- MD, Legal Medicine Research Center, Legal Medicine Organization, Tehran , Iran
[2]- MD, PhD, Legal Medicine Research Center, Legal Medicine Organization, Tehran , Iran, ORCID: 0000-0003-3407-8167
(Corresponding Author) Tel: (071) 36324100, Fax: (071) 36324100, E-mail: zarenezhad@hotmail.com
(Corresponding Author) Tel: (071) 36324100, Fax: (071) 36324100, E-mail: zarenezhad@hotmail.com
[3]- MD, Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran
[4]- MD, Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
[5]- MD, Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran
[6]- MD, Department of Emergency Medicine, School of Medicine, Shiraz University of University of Medical Sciences, Shiraz, Iran
[7]- MD, Department of Emergency Medicine, School of Medicine, Shiraz University of University of Medical Sciences, Shiraz, Iran
Type of Study: Review Article |
Subject:
زيست شناسي
Received: 2022/08/22 | Accepted: 2022/11/28 | Published: 2022/12/19
Received: 2022/08/22 | Accepted: 2022/11/28 | Published: 2022/12/19
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