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JRUMS 2024, 23(3): 164-172 |
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Ethics code: IR. ZBMU. REC.1400.074
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Dabirzadeh M, Hossein Beigi R, Poursamimi J, Arab Yaghoobi L. Investigation of the Serum Levels of TGF-β and IL-6 Cytokines Effective on the Immune System of Diabetic Patients with Toxoplasma Parasitic Infection: A Short Report. JRUMS 2024; 23 (3) :164-172
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Investigation of the Serum Levels of TGF-β and IL-6 Cytokines Effective on the Immune System of Diabetic Patients with Toxoplasma Parasitic Infection: A Short Report
Mansour Dabirzadeh[1], Roghayeh Hossein Beigi[2], Javad Poursamimi[3], Ladan Arab Yaqoubi[4]
Received: 13/01/24 Sent for Revision: 18/03/24 Received Revised Manuscript: 30/06/24 Accepted: 03/07/24
Background and Objectives: Cytokines play an essential role in regulating the interaction of immune cells in diabetes and infections such as toxoplasmosis. This study was conducted to investigate the serum levels of Interleukin-6 (IL-6) and Transforming Growth Factor-Beta (TGF-β) in diabetic patients with toxoplasmosis.
Materials and Methods: This study was conducted in Zabol City on patients with type I and type II diabetes, both with and without toxoplasmosis. The serum levels of target cytokines were measured using the ELISA method. Data analysis was performed using one-way ANOVA, and chi-square test was utilized to examine demographic indices.
Results: A significant increase in TGF-β levels was observed in the group with type II diabetes and toxoplasmosis. Additionally, a slight rise in serum IL-6 levels was noted in the group with type I diabetes. However, the level of TGF-β was decreased in this group.
Conclusions: The present study revealed that an increase in TGF-β and a decrease in IL-6 in patients with type II diabetes and toxoplasmosis may indicate a reduction in inflammation within this specific group.
Keywords: Cytokines, Diabetes, Toxoplasmosis, Inflammation, Immune
Funding: This study was funded by Zabol University of Medical Sciences.
Conflict of interest: None declared.
Ethical considerations: The Ethics Committee of Zabol University of Medical Sciences approved the study (IR.ZBMU.REC.1400.074).
Authors’ contributions:
- Conceptualization: Javad Poursamimi, Mansour Debirzadeh
- Methodology: Javad Poursamimi, Mansour Debirzadeh
- Data collection: Javad Poursamimi, Mansour Debirzadeh, Roghayeh Hossein Beigi
- Formal analysis: Javad Poursamimi
- Supervision: Javad Poursamimi
- Project administration: Javad Poursamimi
- Writing - original draft: Javad Poursamimi, Mansour Debirzadeh
- Writing - review & editing: Ladan Arab Yaqoubi
Citation: Dabirzadeh M, Hossein Beigi R, Poursamimi J, Arab Yaqoubi L. Investigation of the Serum Levels of TGF-β and IL-6 Cytokines Effective on the Immune System of Diabetic Patients with Toxoplasma Parasitic Infection: A Short Report. J Rafsanjan Univ Med Sci 2024; 23 (3): 164-72. [Farsi]
Mansour Dabirzadeh[1], Roghayeh Hossein Beigi[2], Javad Poursamimi[3], Ladan Arab Yaqoubi[4]
Received: 13/01/24 Sent for Revision: 18/03/24 Received Revised Manuscript: 30/06/24 Accepted: 03/07/24
Background and Objectives: Cytokines play an essential role in regulating the interaction of immune cells in diabetes and infections such as toxoplasmosis. This study was conducted to investigate the serum levels of Interleukin-6 (IL-6) and Transforming Growth Factor-Beta (TGF-β) in diabetic patients with toxoplasmosis.
Materials and Methods: This study was conducted in Zabol City on patients with type I and type II diabetes, both with and without toxoplasmosis. The serum levels of target cytokines were measured using the ELISA method. Data analysis was performed using one-way ANOVA, and chi-square test was utilized to examine demographic indices.
Results: A significant increase in TGF-β levels was observed in the group with type II diabetes and toxoplasmosis. Additionally, a slight rise in serum IL-6 levels was noted in the group with type I diabetes. However, the level of TGF-β was decreased in this group.
Conclusions: The present study revealed that an increase in TGF-β and a decrease in IL-6 in patients with type II diabetes and toxoplasmosis may indicate a reduction in inflammation within this specific group.
Keywords: Cytokines, Diabetes, Toxoplasmosis, Inflammation, Immune
Funding: This study was funded by Zabol University of Medical Sciences.
Conflict of interest: None declared.
Ethical considerations: The Ethics Committee of Zabol University of Medical Sciences approved the study (IR.ZBMU.REC.1400.074).
Authors’ contributions:
- Conceptualization: Javad Poursamimi, Mansour Debirzadeh
- Methodology: Javad Poursamimi, Mansour Debirzadeh
- Data collection: Javad Poursamimi, Mansour Debirzadeh, Roghayeh Hossein Beigi
- Formal analysis: Javad Poursamimi
- Supervision: Javad Poursamimi
- Project administration: Javad Poursamimi
- Writing - original draft: Javad Poursamimi, Mansour Debirzadeh
- Writing - review & editing: Ladan Arab Yaqoubi
Citation: Dabirzadeh M, Hossein Beigi R, Poursamimi J, Arab Yaqoubi L. Investigation of the Serum Levels of TGF-β and IL-6 Cytokines Effective on the Immune System of Diabetic Patients with Toxoplasma Parasitic Infection: A Short Report. J Rafsanjan Univ Med Sci 2024; 23 (3): 164-72. [Farsi]
[1]- Associate Prof., Dept. of Parasitology and Mycology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
[2]- Residential Student of Internal Medicine, Department of Internal Medicine, Iran University of Medical Sciences, Tehran, Assistant Professor of Internal Medicine, Department of Internal Medicine, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
[3]- Assistant Prof., Dept. of Immunology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran,
ORCID: 0000-0002-8726-4425
(Corresponding Author) Tel: (054) 32225402, E-mail: Poursj1357@zbmu.ac.ir
ORCID: 0000-0002-8726-4425
(Corresponding Author) Tel: (054) 32225402, E-mail: Poursj1357@zbmu.ac.ir
[4]- Rehabilitation Sciences Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
Type of Study: Research |
Subject:
ايمونولوژي
Received: 2024/01/7 | Accepted: 2024/07/3 | Published: 2024/07/20
Received: 2024/01/7 | Accepted: 2024/07/3 | Published: 2024/07/20
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