TY - JOUR T1 - Effect of Aqueous Extract of the Coriandrum Sativum Seed on the Reduction of Acute and Chronic Pain in Mice TT - اثر عصاره آبی تخم گیاه گشنیز بر کاهش درد حاد و مزمن در موش سوری JF - RUMS_JOURNAL JO - RUMS_JOURNAL VL - 3 IS - 4 UR - http://journal.rums.ac.ir/article-1-32-en.html Y1 - 2004 SP - 243 EP - 249 KW - Acute and Chronic Pain KW - Coriandrum Sativum KW - Formalin Test KW - Mice N2 -   Effect of Aqueous Extract of the Coriandrum Sativum Seed on the Reduction of Acute and Chronic Pain in M ice     AA. Taherian MD ¹*, A. Rashidy-Pour PhD 2 , AA. Vafaei PhD 3 , M. Jarrahi MSc 4 , H. Miladi-Gorgi MSc 4 , M. Emami-Abarghooii PharmD 4 , H. Sadeghi BSc 5     1- Academic Member, Dept. of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran   2- Associated Professor, Dept. of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran   3 – Assistant Professore, Dept. of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan Iran   4- Academic Member, Dept. of Physiology, University of Medical Sciences, Semnan, Iran   5- BSc, Dept of Physiology, Faculty of Medical Sciences, Semnan Iran     Background: Previous investigations have shown that Coriandrum Sativum (CS) extract probably modulates pain in human and animal. The aim of this investigation was assessment of the role of CS on acute and chronic pain by formalin test in mice.   Materials and Methods: In this study, 35 male albino mice in 5 groups (25-30g) were used. CS extract (100, and 200mg/kg), or saline were injected intera-peritoneal (IP) 30 mins before the formalin test. Indices of signs of pain were licking and foot elevation for assessment of acute pain (5 min), and chronic pain (15-40 min) after the injection of formalin 5% (25µl) in the right paw.   Reasults: Results showed that although CS extract has analgesic effect in both doses in acute and chronic pain, (p M3 ER -